摘要
黑色素瘤是恶性程度极高的皮肤肿瘤,发病率在全球内不断上升。尽管近年来靶向治疗得到了长足发展,但耐药性仍是重大障碍,是急需解决的一大难题。越来越多的研究表明,肿瘤微环境通过各种机制参与黑色素瘤发生、发展,为介导黑色素瘤耐药提供了有利条件。因此,研究相关机制有助于寻找逆转黑色素瘤耐药的方案。本文就肿瘤微环境中成纤维细胞、淋巴细胞、巨噬细胞、角质形成细胞、脂肪细胞、树突状细胞等对黑色素瘤靶向治疗耐药性的相关作用机制展开综述。
Melanoma is a highly malignant skin tumor,and its incidence rate is rising all over the world.Despite the rapid development of targeted therapy in recent years,drug resistance is still a major obstacle and a major problem to be solved urgently.More and more studies have shown that tumor microenvironment participates in the occurrence and development of melanoma through various mechanisms,providing favorable conditions for mediating melanoma drug resistance.Therefore,the study of relevant mechanisms is helpful to find a plan to reverse melanoma drug resistance.This paper reviews the mechanism of action of fibroblasts,lymphocytes,macrophages,keratinocytes,fat cells,dendritic cells,etc.on drug resistance in targeted therapy for melanoma in the tumor microenvironment.
作者
刘可微
李建华
郝玉琴
LIU Kewei;LI Jianhua;HAO Yuqin(Psychosomatic Health Examination and Health Care Center,Third Hospital of Inner Mongolia Autonomous Region,Hohhot 010000,China;Department of Dermatology,Third Hospital of Peking University,Beijing 100000,China)
出处
《生命的化学》
CAS
2023年第11期1681-1690,共10页
Chemistry of Life
