摘要
目的基于郁乃痤理论探讨茵陈蒿汤合桃红四物汤治疗湿热瘀结型痤疮的临床效果。方法收集北京中医药大学厦门医院医疗美容科2021年1—12月收治的96例湿热瘀结型痤疮,根据随机数表法分为对照组和试验组,每组各48例。对照组中Ⅱ级患者采用1%阿达帕林凝胶适量涂抹,Ⅲ级及以上患者则在外涂的基础上加用口服米诺环素;试验组患者在对照组治疗的基础上加服茵陈蒿汤合桃红四物汤加减治疗。药物干预2个月,比较两组的治疗效果、皮损变化、血清中的白细胞介素-8(IL-8)、胰岛素样生长因子-1(IGF-1)、肿瘤坏死因子-α(TNF-α)、中医症候评分和皮肤病生活质量指数(DLQI)评分。结果治疗后,两组患者血清IL-8、IGF-1和TNF-α水平较治疗前均明显下降(P<0.05),且试验组较对照组下降更明显(P<0.05);试验组中医症候评分、皮损变化评分和DLQI评分均明显低于对照组(P<0.05);试验组总有效率(91.67%)显著高于对照组(75.00%)(P<0.05)。结论基于郁乃痤理论配伍的茵陈蒿汤合桃红四物汤能够明显改善湿热瘀结型痤疮的皮损程度,降低中医症候评分和DLQI评分,下调血清IL-8、IGF-1和TNF-α水平,提高患者的生活质量和临床治疗效果。
Objective To explore the clinical effect of Yinchenhao Decoction combined with Taohong Siwu Decoction in the treatment of dampness-heat stasis type acne based on the theory of"depression causes acne".Methods A total of 96 cases with dampness-heat stasis type acne admitted to the Medical Aesthetics Department of Xiamen Hospital of Beijing University of Chinese Medicine from January to December 2021 were selected and randomly divided into a control group and a test group,with 48 cases in each group.In the control group,GradeⅡpatients were treated with an external application of 1%adapalene gel,while GradeⅢand above patients were treated with oral minocycline based on the external application;Based on the treatment in the control group,patients in the test group were treated with Yinchenhao decoction and Taohong Siwu decoction.After 2 months of drug intervention,the treatment efficacy,changes in skin lesions,serum levels of interleukin-8(IL-8),insulin-like growth factor-1(IGF-1),tumor necrosis factor-α(TNF-α),traditional Chinese medicine syndrome score,and dermatology life quality index(DLQI)scale scores were compared between the two groups.Results After treatment,the levels of IL-8,IGF-1,and TNF-αin the serum of both groups of patients significantly decreased compared to those before treatment(P<0.05),and the test group showed a more significant decrease compared to the control group(P<0.05).The scores of traditional Chinese medicine symptoms,changes in skin lesions,and DLQI score in the test group were significantly lower than those in the control group(P<0.05).And the total effective rate of the test group(91.67%)was significantly higher than that of the control group(75.00%)(P<0.05).Conclusion The combination of Yinchenhao decoction and Taohong Siwu decoction based on the theory that"depression causes acne"can significantly improve the degree of skin lesions in patients with dampness-heat stasis type acne,reduce the traditional Chinese medicine syndrome score and DLQI score,lower the levels of IL-8,IGF-1,and TNF-αin serum,and ultimately improve the quality of life and clinical treatment effect of patients.
作者
李晓霞
赵文杰
陈华
赵晖
吴育婷
陈慧玲
LI Xiaoxia;ZHAO Wenjie;CHEN Hua;ZHAO Hui;WU Yuting;CHEN Huiling(Xiamen Hospital of Beijing University of Chinese Medicine,Fujian,Xiamen 361009,China)
出处
《中国医药科学》
2023年第23期113-117,共5页
China Medicine And Pharmacy
基金
福建省厦门市医疗卫生指导性项目(3502Z20199059)。
关键词
郁乃痤
湿热瘀结
痤疮
茵陈蒿汤合桃红四物汤
阿达帕林凝胶
Depression causes acne
Dampness-heat stasis
Acne
Yinchenhao Decoction combined with Taohong Siwu Decoction
Adapalene gel
