摘要
细胞铁死亡表型在骨代谢疾病发展过程中发挥重要作用。作为一种程序性细胞死亡方式,铁死亡主要归因于细胞内的脂质过氧化、谷胱甘肽过氧化物酶4抗氧化系统失调以及铁代谢异常,参与多种疾病的发生和发展。笔者总结了铁死亡的发生机制,并从骨细胞、骨髓间充质干细胞、成骨细胞、破骨细胞等骨代谢效应细胞角度,分述骨代谢稳态失衡状态下铁死亡表型的作用机制进展、提出未来研究展望,以期为后续进一步研究骨代谢疾病发生发展机制与治疗策略选择奠定工作基础。
Cellular ferroptosis phenotype plays an important role in the development of bone metabolic diseases.Ferroptosis as a programmed form of cell death is mainly attributed to intracellular lipid peroxidation,dysregulation of the glutathione peroxidase 4 antioxidant system,and abnormal iron metabolism.It is involved in the development and progression of multiple diseases.In this paper,we summarize the mechanisms of ferroptosis and discuss the role of ferroptosis phenotype in the imbalance of bone metabolic homeostasis from the perspective of bone metabolic effector cells,such as osteoblasts,bone marrow mesenchymal stem cells,osteoblasts,and osteoclasts,in order to lay the foundation for further research on the developmental mechanisms of bone metabolic diseases.
作者
秦金然
王亮
王礼宁
朱三木
马勇
谢雁鸣
魏戌
章轶立
QIN Jinran;WANG Liang;WANG Lining;ZHU Sanmu;MA Yong;XIE Yanming;WEI Xu;ZHANG Yili(School of Integrated Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210023;Jiangsu Province Traditional Chinese Medicine Retrogressive Osteoarthritis Clinical Medical Innovation Center,Wuxi 214071;Institute of Clinical Basic Medicine of Traditional Chinese Medicine,Chinese Academy of Traditional Chinese Medicine,Beijing 100700;Wangjing Hospital,China Academy of Chinese Medical Sciences,Beijing 100102,China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2023年第12期1813-1818,1825,共7页
Chinese Journal of Osteoporosis
基金
国家自然科学基金青年科学基金项目(82205140)
江苏省科技计划专项资金(基础研究计划自然科学基金)(BK20220468)
2022-2024年度中华中医药学会青年人才托举工程项目(CACM-2022-QNRC2-B28)
南京中医药大学特聘教授启动资金项目
南京中医药大学罗林秀基金项目(LLX202205)
2023年江苏省研究生科研与实践创新计划(KYCX23_2208)。
关键词
铁死亡
骨质疏松
治疗策略
机制
功能细胞
ferroptosis
osteoporosis
treatment strategy
mechanism
functional cells
