摘要
目的 观察祛浊清源汤联合依帕司他治疗临床期糖尿病肾病(CDN)的临床疗效。方法 将我院116例CDN随机分为观察组例与对照组各58例。对照组口服依帕司他治疗,观察组以祛浊清源汤联合依帕司他治疗。比较两组临床疗效,分别检测肾功能血清肌酐(Scr)、尿素氮(BUN)、肾小球滤过率(GFR)、24h尿蛋白定量(24 h UTP),血脂总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C),血糖中空腹血糖(FBG)、2 h餐后血糖(2 hPBG)、糖化血红蛋白(HbA1c)及同型半胱氨酸(Hcy)、胱抑素-C(Cys-C)水平。结果 治疗后,观察组总有效率高于对照组(P<0.05);两组Scr、BUN、24 hUTP水平均低于治疗前,GFR水平高于治疗前,观察组Scr、BUN、24 hUTP水平均低于对照组,GFR水平高于对照组(P<0.05);两组TC、TG、LDL-C水平均低于治疗前,观察组TC、TG、LDL-C水平均低于对照组(P<0.05);两组FBG、2h PBG、HbA1c水平均低于治疗前,观察组FBG、2 hPBG、HbA1c水平均低于对照组(P<0.05);两组Hcy、Cys-C水平均低于治疗前,观察组Hcy、Cys-C水平均低于对照组(P<0.05)。结论 基于浊郁脉络理论以祛浊清源汤联合依帕司他治疗CDN,能提高临床疗效,缓解肾功能恶化,降血脂,降血糖,降低Hcy、Cys-C水平。
Objective To observe the clinical efficacy of Quzhuo Qingyuan Decoction combined with epalrestat in treatment of clinical diabetes nephropathy(CDN).Methods A total of 116 cases of CDN patients were randomly divided into observation group and control group of 58 cases each.Control group received oral treatment with epalrestat,while observation group received Quzhuo Qingyuan Decoction on the basis of control group.The clinical efficacy of two groups were compared,and renal function,serum creatinine(Scr),urea nitrogen(BUN),glomerular filtration rate(GFR),24-hour urine protein quantification(24 h UTP),blood lipids,total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),fasting blood glucose(FBG),2-hour postprandial blood glucose(2 h PBG),glycosylated hemoglobin(HbA1c),homocysteine(Hcy),cystatin C(Cys-C)levels were measured.Results After treatment,the total effective rate of observation group was higher than control group(P<0.05);the levels of Scr,BUN,and 24 h UTP in both groups were lower than before treatment,and were lower in observation group than control group(P<0.05),while the levels of GFR were higher than control group(P<0.05);the levels of TC,TG,and LDL-C in both groups were lower than before treatment,and were lower in observation group than control group(P<0.05);the levels of FBG,2 h PBG,and HbA1c in both groups were lower than before treatment,and were lower in observation group than control group(P<0.05);the levels of Hcy and Cys-C in both groups were lower than before treatment,and were lower in observation group than control group(P<0.05).Conclusion The combination of Quzhuo Qingyuan Decoction and epalrestat based on the theory of turbid and stagnant meridians improves clinical efficacy,alleviatesrenal function deterioration,loweres blood lipids,blood sugar,and Hcy and Cys-C levels in treatment of CDN.
作者
史红星
高福顺
张静
王鑫
陈立祥
SHI Hong-xing;GAO Fu-shun;ZHANG Jing;WANG Xin;CHEN Li-xiang(Hengshui Hospital of TCM,Hengshui 053000)
出处
《湖北中医药大学学报》
2023年第6期33-36,共4页
Journal of Hubei University of Chinese Medicine
基金
河北省中医药管理局科研计划项目(项目编号:2023534)。
关键词
糖尿病肾病
临床期
浊郁脉络理论
祛浊清源汤
依帕司他
Diabetes nephropathy
Clinical phase
Theory of turbid and depressed veins
Quzhuo Qingyuan Decoction
Epalrestat
