摘要
目的研究颅脑损伤患者去骨瓣减压术后C-反应蛋白/白蛋白比值(CRP/ALB)变化及临床意义。方法选取医院于2020年10月-2022年4月拟行去骨瓣减压术治疗的重型颅脑损伤患者进行前瞻性研究。分别于术前、术后1d、术后3d、术后5d、术后7d测定患者C-反应蛋白(CRP)、白蛋白(ALB)水平。于术后14d,采用格拉斯哥预后评分(COS)评价颅脑损伤患者预后情况,统计患者术后CRP/ALB比值变化情况,并比较不同预后患者术后CRP/ALB数值变化,并分析术后CRP/ALB数值与患者预后的关系。结果去骨瓣减压术后重型颅脑损伤患者CRP、CRP/ALB水平上升,ALB数值下降,且在术后3d时,CRP、CRP/ALB数值上升至顶峰,后逐渐下降;ALB数值下降至低谷,后逐渐回升;术后,90例颅内损伤患者中预后良好39例,占比43.33%。预后良好组术前、术后1d、术后3d、术后5d、术后7d时CRP/ALB数值均小于预后不良组,差异有统计学意义(P<0.05);经点二列相关结果显示,CRP/ALB数值与颅脑损伤患者预后情况成负相关(P<0.05)。结论颅脑损伤患者去骨瓣减压术后CRP/ALB变化与患者预后有关,其值越低,代表患者预后越好。
Objective This paper aims to study the changes and clinical significance of C-reactive protein/albumin ratio(CRP/ALB)in patients with craniocerebral injury after decompressive craniectomy.Methods The patients with severe cranio-cerebral injury who were scheduled to undergo decompressive craniectomy from October 2020 to April 2022 were selected for a prospective study.The levels of C-reactive protein(CRP)and albumin(ALB)were measured before operation,1 day after operation,3 days after operation,5 days after operation and7 days after operation.On the 14"day afer operation,Glasgow Outcome Scale(GOS)was used to evaluate the prognosis of patients with craniocerebral injury,and the change of CRP/ALB ratio after operation was counted.The changes of CRP/ALB values in patients with different prognosis were compared,and the relationship between the CRP/ALB values after operation and the prognosis of patients was analyzed.Results CRP and CRP/ALB levels increased and ALB values decreased in patients with severe craniocerebral injury after decompressive craniectomy,and CRP and CRP/ALB values increased to the peak at 3 days after surgery,and then decreased gradually.The ALB value decreased in a low point and then increased gradually.After operation,39 of 90 patients with intracranial injury had a good prognosis,accounting for 43.33%.The CRP/ALB values before operation,1 day after operation,3 days after operation,5 days after operation and 7 days after operation in the group with good prognosis were lower than those in the group with poor prognosis,with the difference statistically significant(P<0.05).The results of binary correlation showed that CRP/ALB values were negatively correlated with the prognosis of patients with craniocerebral injury(P<0.05).Conclusion The change of CRP/ALB after decompressive craniectomy is related to the prognosis of patients with craniocerebral injury.The lower the value,the better the prognosis of patients.
作者
吴云龙
林聪利
雷兵
WU Yun-long;LIN Cong-li;LEI Bing(Department of Neurosurgery,Xianju Hospital of Traditional Chinese Medicine,Zhejiang 317300,China;不详)
出处
《中国卫生检验杂志》
CAS
2023年第22期2774-2777,共4页
Chinese Journal of Health Laboratory Technology
关键词
颅脑损伤
去骨瓣减压术
C一反应蛋白
白蛋白
Craniocerebral injury
Decompressive craniectomy
C-reactive protein
Albumin
