摘要
目的探讨口腔黏膜下纤维化(OSF)患者采用旴江谢氏刺营疗法配合丹参黏膜下注射治疗的效果。方法将2020年1月至2022年6月该院收治的80例OSF患者随机分为观察组和对照组,每组各40例。对照组予以丹参黏膜下注射治疗,观察组予以旴江谢氏刺营疗法配合丹参黏膜下注射治疗,两组均治疗3个月。比较两组治疗效果、症状体征、血清指标水平。结果观察组治疗总有效率为95.00%,高于对照组的80.00%,差异有统计学意义(P<0.05);两组治疗后视觉模拟评分法评分、张口度和口腔黏膜病损面积均较治疗前改善,并且观察组较对照组改善情况更明显,差异均有统计学意义(P<0.05);两组治疗后血清转化生长因子-β1(TGF-β1)及白细胞介素-6(IL-6)水平均低于治疗前,并且观察组低于对照组,差异均有统计学意义(P<0.05)。结论OSF患者采用旴江谢氏刺营疗法配合丹参黏膜下注射治疗效果满意,可有效改善患者临床症状,调节血清TGF-β1、IL-6水平。
Objective To investigate the effect of acupuncture therapy of Xie′s family in Xujiang combined with Salvia miltiorrhiza injection on oral submucosal fibrosis(OSF).Methods A total of 80 patients with OSF admitted to the hospital from January 2020 to June 2022 were selected as the research objects,and they were divided into observation group and control group,with 40 cases in each group.The control group was treated with salvia miltiorrhiza submucosal injection,and the observation group was treated with acupuncture therapy of Xie′s family in Xujiang and salvia miltiorrhiza submucosal injection.Both groups were treated for 3 months.The therapeutic effects,symptoms and signs,and serum indexes were compared between the two groups.Results The total effective rate of observation group(95.00%)was higher than that of control group(80.00%),the difference was statistically significant(P<0.05).After treatment,the visual analogue scale score,mouth opening degree and oral mucosal lesion area of the two groups were all improved compared with those before treatment,and the improvement in the observation group was more significant than that in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of serum transforming growth factor-β1(TGF-β1)and interleukin-6(IL-6)in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The combination therapy of acupuncture therapy of Xie′s family in Xujiang and salvia miltiorrhiza submucosal injection is effective in the treatment of OSF,which can effectively improve the clinical symptoms and regulate the serum levels of TGF-β1 and IL-6.
作者
黄毅
平江涛
张娟
HUANG Yi;PING Jiangtao;ZHANG Juan(Department of Stomatology,Xinyu Hospital of Traditional Chinese Medicine,Xinyu,Jiangxi 338000,China;Department of Otorhinolaryngology,Xinyu Hospital of Traditional Chinese Medicine,Xinyu,Jiangxi 338000,China)
出处
《检验医学与临床》
CAS
2024年第2期196-198,共3页
Laboratory Medicine and Clinic
基金
江西省卫生健康委科技计划项目(202311806)。
关键词
口腔黏膜下纤维化
丹参注射液
旴江谢氏刺营疗法
临床研究
治疗效果
oral submucosal fibrosis
salvia miltiorrhiza injection
acupuncture therapy of Xie′s family in Xujiang
clinical research
treatment effect
