摘要
免疫逃逸是指恶性肿瘤细胞通过免疫编辑过程后具备浸润、转移等恶性生物学行为,并逃脱免疫系统的监视和清除,最终促进恶性肿瘤病情发生发展的过程。除其他因素外,免疫细胞还积极影响肿瘤发展的每一步,决定了癌细胞在受威胁的微环境中生存的机会。一旦发现第一个癌细胞,抗肿瘤免疫机制就会被激活,并在原发肿瘤形成和转移过程中发挥作用。然而,免疫功能受损时,肿瘤细胞就会通过逃避或者阻挠免疫反应的机制来促进自身的增殖,就会导致肿瘤的持续性发展。而中医药干预癌症免疫逃逸机制需以“扶正”为基本原则,补益正气以治其本,增强免疫细胞对癌细胞的杀伤力,阻止癌症免疫逃逸,从而抑制癌症的发展。根据现有文献分析可知,目前通过免疫逃逸治疗癌症多用补益类药物,这可能是因为机体免疫调节功能与中医“扶正”观点相符合。因此,研究癌症免疫逃逸机制不仅能够提高治疗癌症的效率,而且通过对中医药的开发利用,能够延缓疾病的发展进程,更好的改善患者的生存质量。
Immune escape refers to the process in which malignant tumor cells have malignant biological behaviors such as infiltration and metastasis after immune editing,and escape the surveillance and clearance of the immune system,which ultimately promotes the occurrence and development of malignant tumor.Among other factors,immune cells actively influence every step of tumor development,determining cancer cells′chances of survival in a threatened microenvironment.Once the first cancer cell is found,anti-tumor immune mechanisms are activated and play a role in primary tumor formation and metastasis.However,when immune function is impaired,tumor cells will promote their own proliferation by evading or obstructing the mechanism of immune response,which will lead to the sustainable development of tumors.The mechanism of traditional Chinese medicine intervention in cancer immune escape should be based on the basic principle of"Fuzheng",supplementing the healthy qi to cure its root,enhancing the lethality of immune cells to cancer cells,preventing cancer immune escape,and thus inhibiting the development of cancer.According to the analysis of existing literature,at present,cancer is treated with many supplements through immune escape,which may be because the immune regulation function of the body is consistent with the view of"Fuzheng"in traditional Chinese medicine.Therefore,the study of cancer immune escape mechanism can not only improve the efficiency of cancer treatment,but also delay the development of the disease and better improve the quality of life of patients through the development and utilization of traditional Chinese medicine.
作者
纪柯伊
李根林
吴宿慧
李寒冰
JI Ke-yi;LI Gen-lin;WU Su-hui;LI Han-bing(Henan University of Traditional Chinese Medicine;Henan Engineering Research Center of Healthy Aging Industry,Zhengzhou 450046,China)
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2024年第1期167-174,136,共9页
Natural Product Research and Development
基金
河南省科技攻关计划(232102311191)
河南省高校科技创新团队支持计划(24IRTSTHN040)
河南中医药大学2022年度研究生科研创新类项目(2022KYCX004)。
关键词
免疫逃逸
癌症
中医药
immune escape
cancer
Chinese medicine
