摘要
目的:探究血清25-羟维生素D_(3)[25-(OH)D_(3)]水平与单纯性肥胖患儿营养代谢的关系。方法:回顾性研究2018年1月—2022年12月于日照市妇幼保健院儿科就诊的单纯性肥胖患儿196例,根据血清25-(OH)D_(3)水平分为维生素D(VitD)充足组(n=20)、VitD不足组(n=95)、VitD缺乏组(n=81)。比较三组的一般资料、糖代谢指标、血脂水平及免疫功能,并分析血清25-(OH)D_(3)水平与患儿糖、脂代谢指标的相关性。结果:三组年龄、性别、身高、体重、体重指数(BMI)比较,差异均无统计学意义(P>0.05);三组25-(OH)D_(3)水平比较,差异有统计学意义(P<0.05);三组空腹血糖(FBG)水平比较,差异无统计学意义(P>0.05);三组空腹胰岛素(FIN)、胰岛素抵抗指数(HOMA-IR)比较,差异均有统计学意义(P<0.05);VitD缺乏组的FIN、HOMA-IR均高于VitD充足组、VitD不足组(P<0.05);三组甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平比较,差异均无统计学意义(P>0.05);三组CD8^(+)比较,差异无统计学意义(P>0.05);三组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)比较,差异均有统计学意义(P<0.05);Vit D缺乏组的CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均低于Vit D充足组、Vit D不足组(P<0.05);血清25-(OH)D_(3)水平与单纯性肥胖患儿的FIN、HOMA-IR均成负相关(P<0.05)。结论:单纯性肥胖儿童多存在VitD缺乏情况,VitD缺乏将影响其糖代谢及免疫功能,但对血脂水平的影响较小。
Objective:To explore the relationship between serum 25-hydroxyvitamin D_(3)[25-(OH)D_(3)]level and nutritional metabolism in children with simple obesity.Method:A retrospective study was conducted on 196 children with simple obesity who were treated in the Department of Pediatric,Maternity and Child Health Care of Rizhao from January 2018 to December 2022.According to serum 25-(OH)D_(3) levels,they were divided into vitamin D(VitD)adequate group(n=20),VitD under group(n=95)and VitD deficiency group(n=81).The general data,glucose metabolism indexes,blood lipid levels and immune function of the three groups were compared,and the correlation between serum 25-(OH)D_(3) level and glycolipid metabolism indexes were analyzed.Result:There were no significant differences in age,gender,height,weight and body mass index(BMI)among the three groups(P>0.05).The 25-(OH)D_(3) levels of the three groups were compared,the difference was statistically significant(P<0.05).There was no significant difference in fasting blood glucose(FBG)level among the three groups(P>0.05).The fasting insulin(FIN)and insulin resistance index(HOMA-IR)of the three groups were compared,the differences were statistically significant(P<0.05).The FIN and HOMA-IR of VitD deficiency group were higher than those of VitD adequate group and VitD under group(P<0.05).There were no significant differences in the levels of triglyceride(TG),total cholesterol(TC),low density lipoprotein-cholesterol(LDL-C)and high density lipoprotein-cholesterol(HDL-C)among the three groups(P>0.05).There was no significant difference in CD8^(+)among the three groups(P>0.05).The CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)of the three groups were compared,the differences were statistically significant(P<0.05).The CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in VitD deficiency group were lower than those in VitD adequate group and VitD under group(P<0.05).Serum 25-(OH)D_(3) levels were negatively correlated with FIN and HOMA-IR in children with simple obesity(P<0.05).Conclusion:Children with simple obesity tend to have VitD deficiency,which will affect their glucose metabolism and immune function,but has little effect on lipid level.
作者
李萍
董杰
王向阳
LI Ping;DONG Jie;WANG Xiangyang(Department of Pediatric,Maternity and Child Health Care of Rizhao,Rizhao 276800,China;不详)
出处
《中国医学创新》
CAS
2024年第1期132-136,共5页
Medical Innovation of China
