摘要
患者,男,53岁。反复双下肢结节红斑1年余,发热1个月余。入院前查血常规嗜酸性粒细胞4.92×109/L(55.3%),首诊为“嗜酸性粒细胞增多症”。入院后查EB病毒DNA阳性,下肢皮损病理检查:以血管为中心较致密的单一核细胞浸润,有异型性改变,及数量较多的嗜酸性粒细胞浸润。免疫组化:CD3(+),Ki67(80%),TIA1(+),Granzyme B(+),Perforin(+),EBER(+)。鼻黏膜及喉肿物活检见异型细胞。诊断:结外NK/T细胞淋巴瘤。
A 53-year-old male presented with recurrent skin erythema and subcutaneous nodules of lower extremities for 1 year,fever for more than 1 month.Hematology findings showed a peripheral blood eosinophilic granulocyte count of 4.92×109/L(55.3%),Epstein-Barr virus DNA showed positive.Skin biopsy showed a dense infiltration of mononuclear cells surrounded blood vessels,with atypic changes and a large number of eosinophil infiltration.Immunohistochemistry:CD3(+),Ki67(80%),TIA1(+),Granzyme B(+),Perforin(+),EBER(+).Biopsy of nasal mucosa and laryngeal masses showed heterotypic cells.The diagnosis of extranodal NK/T cell lymphoma(ENKTL)was made.
作者
张蓓蓓
刘立根
宋宁静
ZHANG Beibei;LIU Ligen;SONG Ningjing(Department of Dermatology,Tongren Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200336,China;Department of Hematology,Tongren Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200336,China)
出处
《中国麻风皮肤病杂志》
2024年第2期127-130,共4页
China Journal of Leprosy and Skin Diseases
基金
国家自然科学基金(编号:82103703)。
