摘要
目的:研究吲哚布芬对急性轻型缺血性脑卒中患者神经功能、血小板聚集率及颈总动脉血流的影响。方法:选取本院2021年4月至2022年10月期间104例急性轻型缺血性脑卒中患者随机分组,均给予基础治疗及氯吡格雷,对照组52例给予阿司匹林,观察组52例给予吲哚布芬,于治疗前和治疗4 w后,血小板功能分析仪检测并对比两组患者腺苷二磷酸(Adenosine diphosphate,ADP)诱导的血小板最大聚集率(Maximum platelet aggregation rate induced by ADP,MAR-ADP)和花生四烯酸(Arachidonic acid,AA)诱导的血小板最大聚集率(Maximum platelet aggregation rate induced by AA,MAR-AA)水平,采用彩色多普勒超声仪检测并对比两组患者颈总动脉平均血流速度(Mean velocity,Vm)、平均血流量(Qmean,Qm)、动态阻力(Dynamic resistance,DR)水平,采用美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)、Barthel指数(Barthel index,BI)对比两组患者神经功能状态,并对比两组患者不良反应。结果:治疗后观察组MAR-ADP和MAR-AA水平与对照组比较,差异无统计学意义(P>0.05);治疗后观察组颈总动脉Vm、Qm、DR水平与对照组比较,差异无统计学意义(P>0.05);治疗后观察组NIHSS、BI评分与对照组比较,差异无统计学意义(P>0.05);观察组不良反应总发生率低于对照组(P<0.05)。结论:吲哚布芬治疗急性轻型缺血性脑卒中患者效果与阿司匹林相当,能够有效降低血小板聚集率,改善颈总动脉血流状态,提高患者神经功能,其中吲哚布芬安全性更佳。
Objective:To investigate the effects of indobufen on nerve function,platelet aggregation rate and common carotid artery blood flow in patients with acute mild ischemic stroke.Methods:A total of 104 patients with acute mild ischemic stroke in our hospital from April 2021 to October 2022 were randomly assigned to receive basic therapy and clopidogrel,while 52 patients in the control group received aspirin and 52 patients in the observation group received indolbuprofen before and 4 weeks after treatment.Maximum platelet aggregation rate induced by Adenosine diphosphate(ADP)was detected by platelet function analyzer and compared between the two groups.Maximum platelet aggregation rate induced by ADP,Maximum platelet aggregation rate induced by AA(MAR-AA)and Arachidonic acid(AA)levels,The mean velocity(Vm),mean blood flow(Qmean,Qm)and Dynamic resistance(DR)levels of common carotid artery in the two groups were detected and compared by color Doppler ultrasound instrument.National Institutes of Health Stroke Scale(NIHSS)and Barthel index(BI)were used to compare the neurological function status of the two groups,and the adverse reactions of the two groups were compared.Results:After treatment,there was no significant difference in MAR-ADP and MAR-AA levels between observation group and control group(P>0.05).After treatment,there was no significant difference in Vm,Qm,DR Of common carotid artery between observation group and control group(P>0.05).After treatment,there was no significant difference in NIHSS and BI scores between observation group and control group(P>0.05).The total incidence of adverse reactions in observation group was lower than that in control group(P<0.05).Conclusions:Indobuprofen has the same effect as aspirin in the treatment of patients with acute mild ischemic stroke,which can effectively reduce the rate of platelet aggregation,improve the common carotid artery blood flow status,and improve the neurological function of patients,among which indobuprofen has better safety.
作者
刘营营
李瑞红
赵鑫
曾芳
郭亚珂
Liu Ying-ying;Li Rui-hong;Zhao Xin;Zeng Fang;Guo Ya-ke(Department of Neurology,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 450007,China)
出处
《四川生理科学杂志》
2024年第1期34-36,共3页
Sichuan Journal of Physiological Sciences
