摘要
多系统萎缩(MSA)是一种中枢神经退行性疾病,起病具有隐匿性、散发性、进行性加重的特点。现代医学对其病因及发病机制认识尚不清晰,且治疗方法较为匮乏,中医学对MSA治疗却具有显著优势。现梳理近五年中医药治疗MSA相关文献,从病因病机和辨证论治方面总结其中医药治疗现状,认为MSA多由情志内伤和正虚体弱所致,病机总属肝肾脾亏虚,气、血、水湿运化功能失调。中医药临床多从肝肾亏虚证、脾肾亏虚证和痰瘀互阻证论治,可有效改善自主神经功能障碍、认知功能障碍和躯体运动障碍,并能够延缓MSA中枢神经老化和调节脑内微环境异常,以期为今后中医药治疗MSA提供临床依据和参考。
Multiple system atrophy(MSA) is a central nervous system degenerative illness.MSA starts with occult,sporadic,and growing aggravation.Modern medicine is not clear about its etiology and pathogenesis,and the treatment methods are scarce,but traditional medicine has significant advantages in the treatment of MSA.This study reviews the literature on the treatment of MSA by traditional Chinese medicine in the past five years and summarizes the current status of traditional Chinese medicine treatment from the aspects of etiology,pathogenesis,and syndrome differentiation and treatment.MSA is believed to be mostly caused by emotional internal injury and a weak body.The pathogenesis is always deficiency of the liver,kidney,and spleen,and dysfunction of qi,blood,and water dampness.The clinical treatment of traditional Chinese medicine is mostly based on liver and kidney deficiency syndrome,spleen and kidney deficiency syndrome,and phlegm and blood stasis syndrome.It can effectively improve autonomic nerve dysfunction,cognitive dysfunction,and physical movement disorders,and can delay the aging of the central nervous system of MSA and regulate the abnormal microenvironment in the brain.To provide the clinical basis and reference for the future treatment of MSA with traditional Chinese medicine.
作者
刘云龙
王婧
杨永瑞
赵英慧
李玟茜
郝嘉欣
许蓬娟
樊晓靖
LIU Yunlong;WANG Jing;YANG Yongrui;ZHAO Yinghui;LI Wenxi;HAO Jiaxin;XU Pengjuan;FAN Xiaojing(Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China)
出处
《陕西中医》
CAS
2024年第2期274-277,共4页
Shaanxi Journal of Traditional Chinese Medicine
基金
国家自然科学基金资助面上项目(82274318)。
关键词
多系统萎缩
神经退行性疾病
病因病机
肝肾亏虚
辨证论治
Multiple system atrophy
Neurodegenerative disorders
Pathogenesis
Liver and kidney deficiency
Syndrome differentiation
