摘要
慢性肾脏病(chronic kidney disease,CKD)已经成为影响全球健康的难题,延缓其进展至终末期肾病(end-stage renal disease,ESRD)阶段是治疗CKD的重要目标。缺氧和缺氧诱导因子(hypoxia inducible factor,HIF)与CKD的发生和发展有着密切的联系,HIF表达的增加可以延缓CKD的进程,减少CKD并发症的发生。本文主要从CKD贫血、肾间质纤维化、炎症、血管钙化以及急性肾损伤方面论述了HIF在其中发挥的作用,旨在为延缓CKD进展至ESRD阶段提供新的靶点和思路,改善CKD患者的预后。
Chronic kidney disease(CKD)has become a global health challenge,and delaying its progression to end-stage renal disease(ESRD)is an important goal for our treatment of CKD.Hypoxia and hypoxia inducible factor(HIF)are closely related to the occurrence and development of CKD.The increase in HIF expression can delay the process of CKD and reduce the occurrence of CKD complications.This review mainly discusses the role of HIF in CKD anemia,renal interstitial fibrosis,inflammation,vascular calcification,and acute kidney injury,aiming to provide new targets and ideas for delaying the progression of CKD to the ESRD stage and improving the prognosis of CKD patients.
作者
王欣茹
郭兆安
WANG Xinru;GUO Zhaoan(Shandong University of Traditional Chinese Medicine,Ji’nan 250014,China;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Ji’nan 250014,China)
出处
《生命的化学》
CAS
2023年第12期1922-1926,共5页
Chemistry of Life
基金
2022年度山东省自然科学基金创新发展联合基金项目(ZR202208310056)。
关键词
慢性肾脏病
终末期肾病
缺氧诱导因子
急性肾损伤
chronic kidney disease
end-stage renal disease
hypoxia inducible factor
acute renal injury
