摘要
本研究旨在探讨microRNA(miRNA)在三阴性乳腺癌(TNBC)中的作用。重点介绍了TNBC的背景和临床特征,以及miRNA的基本概念和调控机制。详细描述了TNBC的分子特征,包括基因表达谱的差异和信号通路的异常激活,以及microRNA在TNBC中的作用。进一步讨论了microRNA在TNBC进展中的作用,包括其表达谱、作为TNBC预后标志物的潜力、以及作为TNBC治疗靶点的前景。评述了microRNA的检测和分析方法,以及基于高通量测序的研究策略。总结了对microRNA在TNBC进展中作用的认识,并指出了未来研究的重点和挑战,包括发现和验证新的miRNA靶标、确定miRNA调控网络的机制、以及开发针对microRNA的治疗策略。
The purpose of this study was to investigate the role of microRNA(miRNA)in triple negative breast cancer(TNBC).This paper focuses on the background and clinical features of TNBC,as well as the basic concepts and regulatory mechanisms of mirnas.The molecular characteristics of TNBC were described in detail,including differences in gene expression profiles and abnormal activation of signaling pathways,as well as the role of microRNA in TNBC.The role of microRNA in the progression of TNBC was further discussed,including its expression profile,potential as a prognostic marker for TNBC,and prospect as a therapeutic target for TNBC.The detection and analysis methods of microRNA and the research strategies based on high-throughput sequencing were reviewed.This review summarizes the understanding of the role of micrornas in the progression of TNBC,and identifies priorities and challenges for future research,including the discovery and validation of new miRNA targets,the identification of mechanisms of miRNA regulatory networks,and the development of therapeutic strategies targeting micrornas.
作者
马伟强
马斌林
吴中语
张莹
Ma Weiqiang;Ma Binlin;Wu Zhongyu;Zhang Ying(Breast and Thyroid Surgery Department,Cancer Hospital Affiliated to Xinjiang Medical University,The Clinical Medical Research Center of Breast and Thyroid Tumor in Xinjiang,Urumqi 830011,China)
出处
《中华普外科手术学杂志（电子版）》
2024年第1期111-114,共4页
Chinese Journal of Operative Procedures of General Surgery(Electronic Edition)
