摘要
目的 利用数据挖掘技术分析功能性消化不良(FD)的中医辨证论治规律。方法 检索中国知网、维普资讯中文期刊服务平台、中国生物医学文献服务系统、万方数据知识服务平台收录的FD辨证分型和辨证论治的相关文献,提取文献中的中医证候分布、方药组成等信息,经规范化处理并归类后,运用IBM SPSS Statistics 22.0软件对证型、证素及中药进行频数统计,使用IBM SPSS Modeler 18.0软件对高频药物进行关联规则分析。结果 共获得FD中医证型18个,以肝郁脾虚、脾胃虚弱、肝胃不和、脾胃湿热、寒热错杂为主要证型。肝郁脾虚型常用中药有柴胡、白术等,置信度最高的药对为白芍-柴胡;脾胃虚弱型常用中药有甘草、白术等,置信度最高的药对为茯苓-白术;肝胃不和型常用中药有柴胡、白芍等,置信度最高的药对为白芍-柴胡;脾胃湿热型常用中药有半夏、厚朴等,置信度最高药对为白豆蔻-薏苡仁;寒热错杂型常用中药有半夏、黄连、甘草等,置信度为100%且支持度>90%的药对为甘草-半夏。结论 FD的中医辨证主要为肝郁脾虚、脾胃虚弱、肝胃不和、脾胃湿热、寒热错杂,病位主要在胃,与脾、肝密切相关,病性证素以气滞、气虚为主,中医辨证论治FD的高频用药为白术、柴胡、白芍、茯苓、甘草等,药物功效多为健脾益气、理气止痛。
Objective To analyze the rules of Traditional Chinese Medicine treatment based on syndrome differentiation of functional dyspepsia(FD) by using data mining technique.Methods Literature related to FD syndrome differentiation classification and treatment based on syndrome differentiation recorded in the China National Knowledge Infrastructure,VIP,China Biology Medicine disc,Wanfang Database Knowledge Service Platform was retrieved.Information concerning the distribution of Traditional Chinese Medicine syndromes,compositions of prescriptions,etc.,were extracted from the literature.After normalized process and categorization,the IBM SPSS Statistics 22.0 software was used to perform frequency statistics on syndrome patterns,syndrome elements,and Traditional Chinese Medicines,and association rule analysis was performed on high-frequency drugs by using the IBM SPSS Modeler 18.0 software.Results A total of 18 FD Traditional Chinese Medicine syndrome patterns were obtained,among which the main syndrome patterns contained stagnation of liver qi and deficiency in spleen,hypofunction of spleen and stomach,disharmony between liver and stomach,dampness-heat in spleen and stomach,simultaneous occurrence of cold and heat syndromes.The commonly used Traditional Chinese Medicines of stagnation of liver qi and deficiency in spleen included Radix bupleuri and Atractylodes macrocephala,etc.,and the highest confidence drug-pair was Paeoniae radix alba-Radix bupleuri.The commonly used Traditional Chinese Medicines of hypofunction of spleen and stomach were licorice and Atractylodes macrocephala,etc.,and the highest confidence drug-pair was Poria cocos-Atractylodes macrocephala.The commonly used Traditional Chinese Medicines of disharmony between liver and stomach were Radix bupleuri and Paeoniae radix alba,etc.,and the highest confidence drug-pair was Paeoniae radix alba-Radix bupleuri.The commonly used Traditional Chinese Medicines of dampness-heat in spleen and stomach were Pinellia ternata and Magnolia officinalis,etc.,and the highest confidence drug-pair was Amomum kravanh-Coicis semen.The commonly used Traditional Chinese Medicines of simultaneous occurrence of cold and heat syndromes were Pinellia ternata,Coptidis rhizoma,and licorice,etc.,and drug-pair with 100% confidence and >90% support degree was licorice-Pinellia ternata.Conclusion Traditional Chinese Medicine syndrome differentiation of FD is mainly stagnation of liver qi and deficiency in spleen,hypofunction of spleen and stomach,disharmony between liver and stomach,dampness-heat in spleen and stomach,simultaneous occurrence of cold and heat syndromes,as well as disease locations are mainly in stomach,which are closely related to spleen and liver;moreover,pathogenic syndrome elements are mainly qi stagnation and qi deficiency,and high-frequency medications of Traditional Chinese Medicine treatment based on syndrome differentiation of FD are Atractylodes macrocephala,Radix bupleuri,Paeoniae radix alba,Poria cocos,and licorice,etc.,as well as drug effects are mainly invigorating spleen and replenishing qi,and regulating qi flow to subside pain.
作者
梁巧俐
邹孟龙
黄晓燕
LIANG Qiaoli;ZOU Menglong;HUANG Xiaoyan(Graduate School,Guangxi University of Chinese Medicine,Nanning 530001,Guangxi,China;Graduate School,Hunan University of Chinese Medicine,Changsha 410208,Hunan,China;The Second Ward of Spleen and Stomach Diseases,the First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,Guangxi,China)
出处
《广西医学》
CAS
2023年第22期2749-2755,共7页
Guangxi Medical Journal
关键词
功能性消化不良
中医疗法
证候分布
用药规律
辨证论治
数据挖掘
Functional dyspepsia
Traditional Chinese Medicine therapy
Syndrome distribution
Medication rule
Treatment based on syndrome differentiation
Data mining
