摘要
目的:观察补肾益智方联合盐酸多奈哌齐治疗阿尔茨海默病(AD)的临床疗效及对患者认知能力、脑神经递质及氧化应激相关因子的影响。方法:选取112例AD患者作为研究对象,依据治疗方式不同分为西药组和观察组各56例。西药组给予盐酸多奈哌齐片治疗,观察组在西药组基础上给予补肾益智方治疗。2组均治疗24周。评价2组临床疗效,比较2组治疗前后认知能力、脑神经递质、氧化应激相关因子水平,并观察不良反应发生情况。结果:观察组总有效率为91.07%,高于西药组76.79%(P<0.05)。治疗后,2组简易精神状态量表(MMSE)评分较治疗前升高,观察组高于西药组(P<0.05);2组AD评定量表认知部分(ADAS-cog)评分较治疗前降低,观察组低于西药组(P<0.05)。治疗后,2组血浆多巴胺(DA)、去甲肾上腺素(NE)、5-羟色胺(5-HT)水平较治疗前升高,观察组高于西药组(P<0.05)。治疗后,2组血清谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)水平较治疗前升高,观察组高于西药组(P<0.05);2组血清丙二醛(MDA)水平较治疗前降低,观察组低于西药组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:补肾益智方可改善AD患者认知能力,调节脑神经递质与氧化应激相关因子,有良好安全性。
Objective:To observe the clinical effect of Bushen Yizhi Prescription combined with Donepezil Hydrochloride on Aizheimer's disease(AD)and its effects on cognitive ability,brain neurotransmitters,and oxidative stress-related factors in patients.Methods:A total of 112 AD patients were selected as study objects and were divided into the western medicine group and the observation group according to different treatment methods,with 56 cases in each group.The western medicine group was treated with Donepezil Hydrochloride Tablets,and the observation group was additionally treated with Bushen Yizhi Prescription based on the treatment of the control group.Both groups were treated for 24 weeks.Clinical effects were evaluated in the two groups.Cognitive ability,brain neurotransmitters,and the levels of oxidative stress-related factors were compared between the two groups before and after treatment.The incidence of adverse reactions was observed.Results:The total effective rate was 91.07%in the observation group,higher than that of 76.79%in the western medicine group(P<0.05).After treatment,the scores of Mini-Mental State Examination(MMSE)in the two groups were increased when compared with those before treatment,and the scores in the observation group were higher than those in the western medicine group(P<0.05);the scores of Alzheimer's Disease Assessment Scale-Cognitive Subscale(ADAS-Cog)in the two groups were decreased when compared with those before treatment,and the scores in the observation group were lower than those in the western medicine group(P<0.05).After treatment,the levels of dopamine(DA),norepinephrine(NE),and 5-hydroxytryptamine(5-HT)in plasma in the two groups were increased when compared with those before treatment,and the above levels in the observation group were higher than those in the western medicine group(P<0.05).After treatment,the levels of glutathione peroxidase(GSH-Px)and superoxide dismutase(SOD)in serum in the two groups were increased when compared with those before treatment,and the above two levels in the observation group were higher than those in the western medicine group(P<0.05);the levels of malondialdehyde(MDA)in serum in the two groups were decreased when compared with those before treatment,and the level in the observation group was lower than that in the western medicine group(P<0.05).There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Bushen Yizhi Prescription can improve the cognitive ability of AD patients,regulate brain neurotransmitters and oxidative stress-related factors,and has good safety.
作者
张蔚蓉
赵艳敏
王红震
ZHANG Weirong;ZHAO Yanmin;WANG Hongzhen(Department of Encephalopathy,Hebi Hospital of Traditional Chinese Medicine,Hebi Henan 458030,China)
出处
《新中医》
CAS
2024年第1期35-40,共6页
New Chinese Medicine
关键词
阿尔茨海默病
心肾理论
补肾益智法
认知能力
脑神经递质
氧化应激
Aizheimer's disease
Theory of the heart and kidney
Method of supplementing the kidney and improving intelligence
Cognitive ability
Brain neurotransmitters
Oxidative stress
