摘要
Astrocytes are a major glial cell type in the central nervous system,and they provide trophic and metabolic support to neurons.In addition to these roles,they play crucial roles in modulating synaptic functions,development,and pruning(Brandebura et al.,2023).Astrocytes become reactive(activated)by undergoing morphological,molecular,and functional alterations in response to neuropathology such as in injuries and neurodegenerative diseases(NDs)(Escartin et al.,2021).
基金
supported in part by the R21AG077643,R01NS123571,1U19NS130607,and 5T U24 HG012070(to GZ)
in part by Alzheimer Association Fellowship Award 23AARFD-1029969(to IOS).
