摘要
目的:探讨存活素(Survivin)和细胞周期素依赖性蛋白激酶抑制因子2B(P15INK4B)在骨髓增生异常综合征(MDS)诊断及患者预后评估中的临床价值。方法:选取MDS患者150例为观察组,另选取同期体检健康者150例为对照组,比较Survivin、P15INK4B阳性表达及mRNA相对表达水平。对观察组患者进行为期1年的预后随访,比较不同预后患者Survivin、P15INK4B mRNA相对表达水平。绘制受试者工作特征曲线(ROC)曲线分析Survivin、P15INK4B对MDS的诊断价值,以及对MDS患者不良预后的评估价值。结果:观察组Survivin阳性表达率及mRNA表达水平高于对照组,P15INK4B阳性表达率及mRNA表达水平低于对照组(均P<0.05)。150例MDS患者中50例病死,1年生存率为66.67%(100/150),病死组Survivin mRNA表达水平高于存活组,P15INK4B mRNA表达水平低于存活组(均P<0.05)。Survivin、P15INK4B对MDS均有较高诊断价值,两者联合检测的诊断价值更高(均P<0.05)。Survivin、P15INK4B对MDS患者不良预后均有较高评估价值,两者联合检测的评估价值更高(均P<0.05)。结论:MDS患者Survivin高表达,且与患者预后呈正相关;P15INK4B低表达,且与患者预后呈负相关;两者均可用于MDS的诊断及不良预后的评估,联合检测有更高的价值。
Objective:To investigate the clinical value of Survivin and cyclin dependent kinase inhibitor 2B(P15INK4B)in diagnosis of myelodysplastic syndrome(MDS)and prognosis evaluation of patients.Methods:A total of 150 MDS patients were selected as the observation group,and 150 healthy people in the same period were selected as the control group.The positive expression and mRNA relative expression levels of Survivin and P15INK4B were compared.The patients in the observation group were followed up for 1 year,and the relative expression levels of Survivin and P15INK4B mRNA in patients with different prognosis were compared.ROC curve was drawn to analyze the diagnostic value of Survivin and P15INK4B in MDS and the evaluation value of poor prognosis of MDS patients.Results:The positive expression rate and mRNA expression level of Survivin in the observation group were higher than those in the control group,and the positive expression rate and mRNA expression level of P15INK4B in the observation group were lower than those in the control group(all P<0.05).Among 150 MDS patients,50 patients died,and the 1-year survival rate was 66.67%(100/150).The expression level of Survivin mRNA in the death group was higher than that in the survival group,and the expression level of P15INK4B mRNA was lower than that in the survival group(all P<0.05).Both Survivin and P15INK4B had high diagnostic value for MDS,and the combined detection of Survivin and p15INK4B had a higher diagnostic value(all P<0.05).Survivin and P15INK4B had a high evaluation value for the poor prognosis of MDS patients,and the combined detection of Survivin and p15INK4B had a higher evaluation value(all P<0.05).Conclusion:The expression of Survivin is high in MDS patients and positively correlated with the prognosis of the patients.The expression of P15INK4B was low and negatively correlated with the prognosis of patients.Both of them can be used for the diagnosis of MDS and the evaluation of poor prognosis,and combined detection has higher value.
作者
马丽丽
付长江
MA Lili;FU Changjiang(Department of Hematology,Chifeng Municipal Hospital,Chifeng 024000,China)
出处
《陕西医学杂志》
CAS
2024年第3期348-351,356,共5页
Shaanxi Medical Journal
基金
内蒙古自治区卫生健康委员会医疗卫生科技计划项目(2020MS06524)。
