摘要
目的:观察小剂量泼尼松联合雷公藤多苷治疗老年原发性肾病综合征的效果和安全性。方法:选取2017年3月—2023年2月邢台市信都区人民医院收治的老年原发性肾病综合征患者100例作为研究对象,随机分为对照组和试验组,各50例。在常规治疗基础上,对照组采用小剂量泼尼松治疗,试验组采用小剂量泼尼松联合雷公藤多苷治疗。比较两组肾功能指标[血浆白蛋白、血尿素氮(BUN)、血肌酐(Scr)、24 h尿蛋白]、炎性因子[白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)及肿瘤坏死因子-α(TNF-α)]、不良反应、治疗总有效率。结果:治疗前,两组血浆白蛋白、BUN、Scr、24 h尿蛋白水平比较,差异无统计学意义(P>0.05);治疗后,两组血浆白蛋白水平升高,BUN、Scr和24 h尿蛋白水平降低,试验组血浆白蛋白水平高于对照组,BUN、Scr和24 h尿蛋白水平低于对照组,差异有统计学意义(P<0.05)。治疗前,两组IL-1、IL-6、IL-10、TNF-α水平比较,差异无统计学意义(P>0.05);治疗后,两组IL-1、IL-6、IL-10、TNF-α水平降低,试验组低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。试验组治疗总有效率高于对照组,差异有统计学意义(P=0.037)。结论:小剂量泼尼松联合雷公藤多苷治疗老年原发性肾病综合征的效果较好,能改善肾功能,抑制炎性反应,且不良反应无显著增加。
Objective:To observe the effect and safety of low-dose prednisone combined with tripterygium glycosides in the treatment of primary nephrotic syndrome in the elderly.Methods:One hundred cases of elderly primary nephrotic syndrome patients admitted to Xingtai Xindu District People's Hospital from March 2017 to February 2023 were selected as the study subjects,and randomly divided into the control group and the experimental group,fifty cases each.On the basis of conventional treatment,the control group was treated with small-dose prednisone,and the experimental group was treated with small-dose prednisone combined with tripterygium glycosides.The renal function indexes[plasma albumin,blood urea nitrogen(BUN),serum creatinine(Scr),24 h urinary protein],inflammatory factors[interleukin-1(IL-1),interleukin-6(IL-6),interleukin-10(IL-10)and tumor necrosis factor-α(TNF-α)],adverse reactions and the total effective rate of the treatment were compared between the two groups.Results:Before treatment,there was no statistically significant difference in plasma albumin,BUN,Scr and 24 h urine protein levels between the two groups(P>0.05);after treatment,plasma albumin level increased,BUN,Scr and 24 h urine protein level decreased in both groups,and plasma albumin level was higher in the experimental group than that in the control group,and BUN,Scr and 24 h urine protein levels were lower than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,the levels of IL-1,IL-6,IL-10 and TNF-αin the two groups were compared,and the difference was not statistically significant(P>0.05);after treatment,the levels of IL-1,IL-6,IL-10 and TNF-αin the two groups decreased,and the experimental group was lower than the control group,with statistically significant differences(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The total effective rate of treatment in the experimental group was higher than that in the control group,and the difference was statistically significant(P=0.037).Conclusion:Small-dose prednisone combined with tripterygium glycosides is more effective in the treatment of primary nephrotic syndrome in the elderly,which can improve renal function and inflammatory reactions,and there is no significant increase in adverse reactions.
作者
张晓冰
Zhang Xiaobing(Department of Nephrology,Xingtai Xindu District People's Hospital,Xingtai 054001,Hebei Province,China)
出处
《中外医药研究》
2023年第32期96-98,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
泼尼松
雷公藤多苷
原发性肾病综合征
老年患者
Prednisone
Tripterygium glycosides
Primary nephrotic syndrome
Elderly patients
