摘要
目的观察银连含漱液防治鼻咽癌放疗引起的急性放射性口咽黏膜炎的临床疗效。方法将32例初次行放疗的鼻咽癌患者随机分为试验组(19例)和对照组(13例),两组在放疗、化疗的基础上,试验组予银连含漱液漱口,对照组予生理盐水漱口。观察两组患者干预前后严重急性放射性口咽黏膜炎的发生率,出现口咽部不适、口咽部疼痛的时间和程度(NRS评分)、生活质量评分(QOL-NPC评分)、出现放疗毒副作用(SE-QOLNPC评分)及口干症状(SE1评分)的时间及程度。结果放疗至第6周时,试验组Ⅲ级及以上的放射性口咽黏膜炎的发生率显著低于对照组(P<0.001);放疗结束后1个月,试验组I级及以上的放射性口咽黏膜炎的发生率显著低于对照组(P<0.001)。从放疗第2周开始,试验组咽部不适NRS评分低于对照组(P<0.05);从放疗第4周开始口腔及口咽部疼痛NRS评分低于对照组(P<0.05);从放疗第5周开始试验组SE1评分高于对照组(P<0.05);在放疗结束后1个月,试验组咽部不适NRS评分、口腔及口咽部疼痛NRS评分低于对照组(P<0.001),QOL-NPC评分、SE-QOL-NPC评分和SE1评分均高于对照组(P=0.05或P<0.05)。结论鼻咽癌患者在放疗期间使用银连含漱液,可以显著减少严重的急性放射性口咽黏膜炎的发生,有效延迟和缓解急性放射性口咽黏膜炎的相关症状,提高患者放疗期间的生活质量,且在放疗结束1个月后,对急性放射性口咽黏膜炎仍有较好的疗效。
Objective To observe the clinical efficacy of Yinlian Gargle in the treatment of acute radiation-induced oropharyngeal mucositis after nasopharyngeal carcinoma radiotherapy.Methods Thirty-two patients with nasopharyngeal carcinoma,who had received first radiation,were randomly split into two groups:the trial group(19 cases)and the control group(13 cases).After all groups were treated with radiotherapy and chemotherapy,the control group was given rinse treatment with saline whereas the trial group was given Yinlian Gargle.The incidence of severe acute radiation-induced oropharyngeal mucositis,the duration and intensity of oropharyngeal discomfort and pain(NRS score),quality of life(QOL-NPC score),duration and intensity of radiation-induced side effects(SE-QOL-NPC score)and symptoms of dry mouth(SE1 score)were monitored before and after intervention in two groups.Results The incidence of gradeⅢor above radiation-induced oropharyngeal mucositis until the sixth week of radiotherapy in the trial group was considerably lower than that in the control group(P<0.001),while the incidence of grade I or above radiation-induced oropharyngeal mucositis at 1 month after radiotherapy in the trial group was obviously lower than that in the control group(P<0.001).The NRS score of pharyngeal discomfort of the trial group was lower than that of the control group starting from the second week of radiotherapy(P<0.05).The NRS score of oral and oropharyngeal pain was lower than that of the control group starting from the fourth week of radiotherapy(P<0.05).The SE1 score of the trial group was higher than that of the control group starting from the fifth week of radiotherapy(P<0.05).After one month of the completion of the radiotherapy,the NRS score of pharyngeal discomfort and the NRS score of oral and oropharyngeal pain in the trial group were lower than those of the control group(P<0.001).The QOL-NPC score,SE-QOL-NPC score,and SE1 score were all higher than those in the control group(P=0.05 or P<0.05).Conclusion Patients with nasopharyngeal cancer can greatly reduce their risk of developing severe acute radiation-induced oropharyngeal mucositis,effectively delay and relieve related symptoms,and enhance quality of life by consistently using Yinlian Gargle during radiotherapy.Additionally,a month after the completion of radiotherapy,it still has positive therapeutic effects on acute radiation-induced oropharyngeal mucositis.
作者
方彩珊
肖佩琪
钟毓
汪咏春
张驰名
周敏
闫亚杰
阮岩
FANG Caishan;XIAO Peiqi;ZHONG Yu;WANG Yongchun;ZHANG Chiming;ZHOU Min;YAN Yajie;RUAN Yan(The First Clinical Medical School of Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China;The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610000 Sichuan,China;The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China;Department of Allergy,The Third Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510630 Guangdong,China;Lingnan Institute of Otolaryngology,Guangdong Clinical Research Academy of Chinese Medicine,Guangzhou 510405 Guangdong,China)
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2024年第1期141-147,共7页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
国家自然科学基金面上项目(82274590)
国家自然科学基金面上项目(81974581)
广东省基础与应用基础研究基金项目区域联合基金-青年基金(2021A1515110446)
广州市科技基础与应用基础研究项目(一般项目,博士青年科技人员类,202201011211)。
关键词
银连含漱液
鼻咽癌
急性放射性口咽黏膜炎
临床疗效
Yinlian Gargle
nasopharyngeal carcinoma
acute radiation-induced oropharyngeal mucositis
clinical effects
