摘要
胎儿出生体重是妊娠结束时评估胎儿生长状况的最直观指标,但其作为一个单一的衡量指标并不能反映整个妊娠期胎儿生长的动态变化,相似的出生体重可能沿着不同的生长轨迹获得。目前胎儿生长受限或巨大儿等诊断是基于估计胎儿体重或腹围的横断面临界值判断的,而横断面测量可能会遗漏某些未能达到其潜能、但仍高于传统临界值的胎儿亚组,这些亚组的胎儿同样面临不良围产结局的风险。对胎儿生长进行纵向评估可能是解决这一临床问题的有效方法之一。本文从胎儿宫内及出生后生长轨迹的影响因素、不同轨迹下胎儿的远期健康结局等方面进行综述,以期为相关领域的进一步研究提供参考。
Fetal birth weight is the most intuitive indicator to evaluate fetal growth status at the end of pregnancy,but as a single measure,it cannot reflect the dynamic changes in fetal growth throughout the entire pregnancy.Similar birth weights may be achieved along different growth trajectories.At present,the diagnosis of fetal growth restriction or macrosomia is based on cross-sectional threshold values of estimated fetal weight or abdominal circumference,which may overlook certain subgroups of fetuses that do not reach their potential but still exceed traditional threshold values.Fetuses in these subgroups also face the risk of adverse perinatal outcomes.Longitudinal assessment of fetal growth may be one of the effective ways to address this clinical problem.This article provides a comprehensive review of factors influencing the fetal growth trajectories both in utero and after birth,as well as the long-term health outcomes of fetuses on different trajectories,so as to provide reference for further research in the field of related.
作者
王亚新
马良坤
孙崟
高劲松
刘娜娜
杨萱瑾
WANG Yaxin;MA Liangkun;SUN Yin;GAO Jinsong;LIU Nana;YANG Xuanjin(National Clinical Research Center for Obstetric&Gynecologic Diseases,Chinese Academy of Medical Sciences&Peking Union Medical College,Department of Obstetrics and Gynecology,Peking Union Medical College Hospital,Beijing 100730,China)
出处
《中国妇幼健康研究》
2024年第3期81-87,共7页
Chinese Journal of Woman and Child Health Research
基金
国家重点研发计划(2022YFC2703304)
妊娠期糖尿病妇女体重增长推荐值标准项目(20191901)
中国医学科学院中央级公益性科研院所基本科研业务费临床与转化医学研究基金项目(2019XK320007)
中国医学科学院医学与健康科技创新工程项目(2020-I2M-2-009、2021-I2M-1-023)。
关键词
胎儿生长轨迹
宫内发育
生命早期健康
生长发育
模型
fetal growth trajectory
intrauterine development
healthy early in life
growth and development
model
