摘要
群体感应系统通过感知细菌密度来调节与其生长、代谢等行为相关基因的表达,操控整个细菌群体统一行动,来保证细菌代谢产物的正常分泌和生物膜微环境的稳定,为生物膜形成和细菌的正常生长繁殖提供保障。中药具有群体感应抑制作用,可抑制细菌生物膜的形成,降低细菌耐药性,与抗生素联用能增强抗生素的抗感染能力。近年来,中西药联用治疗耐药细菌感染已成研究热点,该文从群体感应、生物膜与耐药细菌的关联入手,并对将中药作为群体感应抑制剂与抗生素协同抑制耐药细菌的国内外相关研究进行整理归纳,旨在为临床新治疗方式和新型抗感染药物的研发提供思路。
Quorum sensing system regulates the expression of genes related to bacterial growth,metabolism and other behaviors by sensing bacterial density,and controls the unified action of the entire bacterial population.This mechanism can ensure the normal secretion of bacterial metabolites and the stability of the biofilm microenvironment,providing protection for the formation of biofilms and the normal growth and reproduction of bacteria.Traditional Chinese medicine,capable of quorum sensing inhibition,can inhibit the formation of bacterial biofilms,reduce bacterial resistance,and enhance the anti-infection ability of antibiotics when combined with antibiotics.In recent years,the combination of traditional Chinese and Western medicine in the treatment of drug-resistant bacterial infections has become a research hotspot.Starting with the associations between quorum sensing,biofilm and drug-resistant bacteria,this paper reviews the relevant studies about the combined application of traditional Chinese medicines as quorum sensing inhibitors with antibiotics in the treatment of drug-resistant bacteria.This review is expected to provide ideas for the development of new clinical treatment methods and novel anti-infection drugs.
作者
刘新越
李晨铭
吕春晓
李自强
黄宇虹
LIU Xin-yue;LI Chen-ming;LYU Chun-xiao;LI Zi-qiang;HUANG Yu-hong(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300250,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2024年第3期653-660,共8页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(82374250)
天津市教委科研计划项目(2021ZD017,2022ZD051)
天津市研究生科研创新项目(2022BKY192)
天津中医药大学研究生科研创新项目(YJSKC-20221018)。
关键词
中西药联用
耐药细菌
群体感应系统
生物膜
协同抑制
combination of traditional Chinese and Western medicine
drug-resistant bacteria
quorum sensing system
biofilm
synergistic inhibition
