摘要
目的探讨玻璃酸钠注射液+塞来昔布对膝骨关节炎患者的临床疗效的影响。方法随机选取2022年1月—2023年8月镇江三五九医院收治的90例膝骨关节炎患者为研究对象,依照随机数表法分成对照组和研究组,各45例。对照组应用玻璃酸钠注射液治疗,研究组联合应用玻璃酸钠注射液+塞来昔布治疗,均持续治疗10周。两组的总有效率、治疗前后的血清炎性因子指标、疼痛评分、膝关节功能评分、生活质量评分。结果研究组总有效率为97.78%高于对照组的82.22%,差异有统计学意义(χ^(2)=6.049,P<0.05)。治疗后,研究组血清C反应蛋白、白细胞介素-6水平均较对照组更低,差异有统计学意义(P均<0.05),研究组的疼痛评分比对照组低,差异有统计学意义(P<0.05),研究组的膝关节功能评分、生活质量4个维度评分均比对照组高,差异有统计学意义(P均<0.05)。结论将玻璃酸钠注射液与塞来昔布联合用于治疗膝骨关节炎可增强对患者关节炎症反应、疼痛的缓解作用,病情控制效果良好,有利于改善患者膝关节功能,提升其生活质量水平。
Objective To explore the clinical effect of sodium hyaluronate injection+celecoxib on patients with knee osteoarthritis.Methods 90 patients with knee osteoarthritis admitted to Zhenjiang 359 Hospital from January 2022 to August 2023 were randomly selected as research subjects and divided into control group and study group according to the random number table method,with 45 cases each.The control group was treated with sodium hyaluronate injec⁃tion,and the study group was treated with sodium hyaluronate injection+celecoxib,both group continued for 10 weeks.The total effective rate and the serum inflammatory factor indexes,pain scores,knee function scores,and qual⁃ity of life scores were compared between the two groups before and after treatment.Results Regarding the total effec⁃tive rate was 97.78%in the study group,which was higher than 82.22%in the control group,the difference was statis⁃tically significant(χ^(2)=6.049,P<0.05).After treatment,serum C-reactive protein and interleukin-6 levels in the study group were lower than in the control group,the differences were statistically significant(both P<0.05).Pain scores in the study group were lower than in the control group,the difference was statistically significant(P<0.05).Knee func⁃tion scores and four dimensions of quality of life scores in the study group were higher than in the control group,the differences were statistically significant(all P<0.05).Conclusion The combination of sodium hyaluronate injection and celecoxib for the treatment of knee osteoarthritis can enhance the alleviation of patients'joint inflammatory re⁃sponse and pain,and the condition control effect is good,which is conducive to the improvement of patients'knee joint function and the enhancement of their quality of life level.
作者
王艳
曹华
丁妍
WANG Yan;CAO Hua;DING Yan(Zhenjiang 359 Hospital,Zhenjiang,Jiangsu Province,212004 China)
出处
《中外医疗》
2024年第1期118-121,共4页
China & Foreign Medical Treatment
关键词
膝骨关节炎
玻璃酸钠注射液
塞来昔布
Knee osteoarthritis
Sodium hyaluronate injection
Celecoxib
