摘要
目的 了解新型冠状病毒感染(COVID-19)流行前后,2018年1月—2023年6月浙江省杭州市儿童呼吸道合胞病毒(RSV)感染和流行病学特征。方法 选择2018年1月—2023年6月浙江省人民医院门诊及住院收治的21 453例儿童患者为研究对象,对病例信息进行统计学分析。患者标本通过聚合酶链式反应(PCR)荧光探针法检测RSV病毒RNA。结果 2018—2022全年和2023年1~6月分别检测样本3 970例、4 109例、2 134例、5 845例、4 198例、1 197例,阳性率分别为20.30%、9.17%、17.15%、26.30%、11.58%、11.19%。2018-2022年不同年份患儿的RSV阳性率比较有统计学意义(P<0.05)。与2019年相比,2020、2021和2022年RSV阳性率上升(P<0.05)。阳性率存在季节差异,冬季较高,但在2021年夏季和2023年春季出现反季节性升高。12 479例男性患儿中RSV阳性率16.93%(2 113/1 2479),8 974例女性患儿中RSV阳性率16.64%(1 493/8 974),不同性别患儿的RSV阳性率比较,无统计学差异。在年龄方面,最容易感染的年龄组是婴儿期。结论 本研究揭示了2018年1月—2023年6月杭州地区儿童患者RSV感染情况及流行病学特征;RSV的流行与季节和年龄有关,此外,公共卫生措施或策略是影响RSV流行病学变化的重要原因。
OBJECTIVE To understand the epidemiological characteristics of respiratory syncytial virus(RSV)in-fection in children of Hangzhou,Zhejiang Province before and after COVID-19 epidemic from Jan 2018 to Jun 2023.METHODS A total of 21453 children who were treated in the outpatient department and hospitalized in Zhe-jiang Province People's Hospital from Jan 2018 to Jun 2023 were recruited as the research subjects.The informa-tion of the cases was statistically analyzed.The RNA of RSV was detected by means of polymerase chain reaction(PCR)fluorescent probe method.RESULTS Totally 3970 cases of samples were detected in 2018,4109 cases in 2019,2134 cases in 2020,5845 cases in 2021,4198cases in 2022,1197 cases in Jan-Jun 2023;the positive rates were 20.30%,9.17%,17.15%,26.30%,11.58%and 11.19%,respectively.There was significant differ-ence in the positive rate of RSV among the years from 2018 to 2022(P<0.05).The positive rate of RSV was higher in 2020,2021 and 2022 than in 2019(P<0.05).The positive rate varied in the seasons,it was higher in winter,while the positive rate showed counterseasonal rise in summer of 2021 and spring of 2023.The positive rate of RSV was 16.93%(2113/12479)among the 12479 male children,the positive rate of RSV was 16.64%(1493/8974)among the 8974 female children,and there was no significant difference in the positive rate of RSV between the male children and the female children.In terms of the age,the infancy was the age group that was the most susceptible to the infection.CONCLUSION The article reveals the prevalence and epidemiological characteristics of RSV infection among the children of Hangzhou from Jan 2018 to Jun 2023.The prevalence of RSV is associated with the season and age,in addition,the public health measures or strategies are the leading causes for the epidemiological change of RSV.
作者
黄晓文
庞珍珍
周斐斐
张能华
解鸿翔
HUANG Xiao-wen;PANG Zhen-zhen;ZHOU Fei-fei;ZHANG Neng-hua;XIE Hong-xiang(Jiaring Hospital of Traditional Chinese Medicine,Jiaring,Zhejiang 314033,China;不详)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2024年第6期907-911,共5页
Chinese Journal of Nosocomiology
基金
山东省自然科学基金资助项目(ZR2020MH116)
浙江省医药卫生科技计划基金资助项目(2021KY017、2022KY027)
浙江省教育厅一般科研基金资助项目(Y202146133)
浙江省中医药科技计划基金资助项目(2023ZL009)
浙江省高校基本科研经费专项基金资助(KYYB202216)。
