摘要
自身免疫性疾病传统治疗自身免疫性疾病的药物会产生诸多不良反应,且目前治疗的方式多侧重于症状的控制而不是治愈,给人们造成了巨大的健康问题和经济负担。近年来,临床研究证明某些蠕虫及其衍生产物治疗自身免疫性疾病具有明显的治疗效果,而其作为一种近天然的免疫调节剂,作用相较于治疗自身免疫性疾病的广谱免疫抑制剂和皮质类固醇更加温和。但不同的蠕虫及其衍生产物治疗自身免疫性疾病的机制与效果也不尽相同。本文主要总结了蠕虫及其衍生产物治疗炎症性肠病、多发性硬化症和自闭症谱系障碍的临床进展,以提供新的临床治疗思路。
Traditional medications used for treating autoimmune diseases often come with a wide range of adverse effects.Current treatments focus mainly on symptom management,resulting in significant health issues and financial burdens for patients.Recently,clinical research has demonstrated the potential of helminths and their derivatives as effective therapies for autoimmune disorders.Helminths,being a near-natural immunomodulator,exhibit milder effects than broad-spectrum immunosuppressants and corticosteroids,thereby presenting a promising alternative for the treatment of autoimmune diseases.However,different helminths'therapeutic efficacy and mechanisms and their derivatives in treating autoimmune diseases may vary.Therefore,we aim to review recent clinical advancements in the use of helminths and their derivatives for treating inflammatory bowel disease,multiple sclerosis,and autism spectrum disorder,with a view to offering novel clinical treatment approaches.
作者
吴心悦
高宏宇
段姝瑶
丁文博
杨小迪
WU Xinyue;GAO Hongyu;DUAN Shuyao;DING Wenbo;YANG Xiaodi(Anhui Provincial Key Laboratory of Infection and Immunity,Bengbu Medical College,Bengbu 233030,China;Department of Pediatrics,First Affiliated Hospital of Bengbu Medical College,Bengbu Medical College,Bengbu 233030,China;Department of Microbiology and Parasitology,Bengbu Medical College,Bengbu 233030,China)
出处
《细胞与分子免疫学杂志》
CAS
CSCD
北大核心
2023年第12期1132-1140,共9页
Chinese Journal of Cellular and Molecular Immunology
基金
安徽省高校学科(专业)拔尖人才学术资助项目(gxbjZD15)
安徽省自然科学基金(2008085MH260)
蚌埠医学院自然科学高层次科技项目立项攀登计划(2020bypd007)
蚌埠医学院“512人才培育计划”(by51201205)
蚌埠医学院省级重点科研开放课题基金(KLICD-2022-Z1)
蚌埠医学院研究生科研创新计划(Byycxz20016)。
关键词
蠕虫
自身免疫性疾病
临床进展
综述
helminths
autoimmune disease
clinical progress
review
