摘要
目的:分析我院前五位细菌耐药率与近五年抗菌药物使用频度(DDDs)的相关性,为今后抗菌药物的合理使用提供依据。方法:统计2018-2022年检出前五位细菌的耐药率,以及同期抗菌药物的DDDs,并对两者进行相关性分析。结果:检出的前五位细菌分别是大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌、鲍曼不动杆菌和金黄色葡萄球菌,其中大肠埃希菌对左氧氟沙星的耐药率逐年上升。细菌耐药率与抗菌药物DDDs相关性分析发现,大肠埃希菌耐药率与左旋氧氟沙星正相关(r值为0.902,P<0.05);肺炎克雷伯菌耐药率与头孢唑林呈正相关(r值为0.902,P<0.05);鲍曼不动杆菌耐药率与头孢哌酮舒巴坦正相关(r值为0.965,P<0.05)。金黄色葡萄球菌与常用抗菌药物之间无相关性(P0.05)。结论:某类细菌的耐药率与抗菌药物使用存在相关性,提醒临床医生使用抗菌药物时应进行适当调整,促进合理用药,降低耐药率的发生。
Objective:To analyze the correlation between the top five bacterial drug resistance rates and antimicrobial drug use frequency(DDDs),understand the trend of bacterial drug resistance in our hospital,and provide basis for the rational use of antimicrobial drugs.Methods:The drug resistance rate of the top five bacteria clinically isolated from 2018 to 2022 and the DDDs of antibacterial drugs in the same period were counted.Pearson was used to analyze the correlation between the drug resistance rate of bacteria and the DDDs of antibacterial drugs.Results:The top five bacteria detected in 2018-2022 were Escherichia coli,Klebsiella pneumoniae,Pseudomonas aeruginosa,Acinetobacter baumanni and Staphylococcus aureus.The drug resistance rate of Escherichia coli to levofloxacin increased year by year.According to the statistics of DDDs,levofloxacin is the most widely used antibiotic.The correlation analysis between bacterial drug resistance rate and DDDs showed that the drug resistance rate of Escherichia coli was positively correlated with levofloxacin(r=0.902,P<0.05);The drug resistance rate of Klebsiella pneumoniae was positively correlated with cefazolin(r=0.902,P<0.05);The drug resistance rate of Acinetobacter baumanni was positively correlated with cefoperazone sulbactam(r-0.965,P<0.05).There was no correlation between Staphylococcus aureus and common antibiotics(P>0.05).Conclusion:There is a correlation between the drug resistance rate of the bacteria and the use of antibacterial drugs.Appropriate adjustment should be made to promote rational drug use and reduce drug resistance.
作者
王素红
于子倩
李姗姗
钟喜杰
WANG Su-hong;YU Zi-qian;LI Shan-shan(Clinical laboratory,Liaocheng Veterans Hospital,Shandong Liaocheng 252000)
出处
《医学检验与临床》
2024年第2期28-32,共5页
Medical Laboratory Science and Clinics
关键词
前五位细菌
抗菌药物
耐药率
DDDS
相关性
Top five bacteria
Antimicrobial drugs
Drug resistance rate
DDDs
Relevance
