摘要
目的:探究类风湿关节炎伴发甲状腺功能异常的情况和临床意义。方法:采用回顾性研究的方法,纳入871例RA患者为病例组,1742名健康体检者为对照组。回顾性分析免疫学指标、甲状腺功能及常规的实验室检查项目,评估RA患者的甲状腺功能状况,并对类风湿关节炎患者中甲状腺功能异常和正常的自身抗体、常规实验室检查项目进行组间比较及相关性分析。结果:RA组甲状腺功能异常216例(24.80%),对照组甲状腺功能异常204例(11.71%),两组差异有统计学意义(P<0.05)。其中,甲状腺功能亢进11例,亚临床型甲状腺功能亢进1例,甲状腺功能减退132例,亚临床型甲状腺功能减退64例,低T3/T4综合征8例。RA组TSH、TPOAb较对照组升高(P<0.01,P<0.05),TT3、FT3较对照组降低(P<0.01,P<0.05);甲状腺功能异常和正常RA患者ANA抗体阳性率差异有统计学意义(P<0.05)。结论:RA患者易伴发甲状腺功能异常,以甲状腺功能低下最为常见,有必要定期进行甲状腺筛查。
Objevtive:To explore the situation and clinical significance of rheumatoid arthritis with thyroid dysfunction.Methods:A retrospective study was carried out,including 871 RA patients as the case group and 1742 healthy persons as the control group.The immunologic indexes,thyroid function and routine laboratory examination items were retrospectively analyzed to evaluate the thyroid function of RA patients,and the abnormal and normal thyroid autoantibodies and routine laboratory tests of RA patients were compared between groups and the correlation analysis was performed.Results:There were 216(24.80%)abnormal thyroid function in RA group and 204(11.71%)abnormal thyroid function in control group.The difference between the two groups was statistically significant(P<0.05).Among them,there were 11 cases of hyperthyroidism,1 case of subclinical hyperthyroidism,132 cases of hypothyroidism,64 cases of subclinical hypothyroidism,and 8 cases of low T3/T4 syndrome.TSH and TPOAb in RA group were higher than those in control group(P<0.01,P<0.05),while TT3 and FT3 were lower than those in control group(P<0.01,P<0.05).There was a significant difference in the positive rate of ANA antibody between patients with abnormal thyroid function and normal RA(P<0.05).Conclusion:Patients with RA are prone to have abnormal thyroid function,and hypothyroidism is the most common.It is necessary to carry out thyroid screening regularly.
作者
杨显娜
殷建美
王志敏
晏蔚田
王兴强
刘维超
凌丽
唐海倩
孟凡雨
张昊喆
彭江云
YANG Xianna;YIN Jianmei;WANG Zhimin;YAN Weitian;WANG Xingqiang;LIU Weichao;LING Li;TANG Haiqian;MENG Fanyu;ZHANG Haozhe;PENG Jiangyun(The First Clinical Medical College of Yunnan University of Chinese Medicine,Kunming 650011,China;Baoshan College of Traditional Chinese Medicine,Baoshan 678000,China;The First Affiliated Hospital of Yunnan University of Chinese Medicine,Kunming 650021,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2024年第3期1517-1521,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家中医药管理局国家中医(类风湿关节炎)临床研究基地建设项目(No.中国中医药科技函[2018]131号)
国家自然科学基金项目(No.82160901,No.81960863)
云南省中医(风湿病)临床医学研究中心项目(No.202102AA310006)
云南省中医药学科后备人才培养项目(No.云卫中医发展发[2021]1号)
云南省科技厅云南中医学院应用基础研究联合专项(No.202101AZ070001-201)。
关键词
关节炎
类风湿
甲状腺功能
回顾性研究
Arthritis
Rheumatoid
Thyroid function
Retrospective study
