摘要
射血分数保留型心力衰竭是休息或运动时左室充盈压增高,出现以心力衰竭症状或体征为表现的一种临床综合征。心外膜脂肪组织(EAT)对射血分数保留型心力衰竭的发生发展起着关键作用,目前尚无特效药物治疗。从“结”病的视角认识射血分数保留型心力衰竭合并心外脂肪组织,发现微血管炎症与心脏底物利用和能量代谢是其核心病机。基于“结者散之”理论,探讨通过散结减轻炎症反应、维持心肌能量稳态、抑制心肌纤维化,进而对射血分数保留型心力衰竭发挥积极治疗作用。
Heart failure with preserved ejection fraction(HFpEF)is a clinical syndrome characterized by increased left ventricular filling pressure at rest or exercise and the appearance of symptoms or signs of heart failure.It has been well established that epicardial adipose tissue(EAT)plays a critical role in the development of HFpEF,and there is no specific treatment for this condition.From the perspective of"accumulation"disease,it was found that microvascular inflammation,substrate utilization,and energy metabolism were the core pathogenesis of HFpEF combined with EAT.Based on the"treating pathogenic accumulation with dissipation"theory,this article explored the positive therapeutic effect of HFpEF by dispersing knot to reducing inflammatory response,maintaining myocardial energy homeostasis,and inhibiting myocardial fibrosis.
作者
潘纬榕
姚成增
李颖
PAN Weirong;YAO Chengzeng;LI Ying(Jing'an District Hospital of Traditional Chinese Medicine,Shanghai 200072,China;Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200021,China)
出处
《中医药导报》
2024年第3期180-184,197,共6页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
国家中医药管理局第六批全国老中医药专家学术经验继承工作项目(国中医药人教发〔2017〕29)
静安区中医药临床重点专科建设项目(JA2020-Z004)
芪精慧心方治疗冠状动脉微血管性心绞痛的多中心临床研究项目(SHDC12018X29)。
关键词
射血分数保留型心力衰竭
“结者散之”
中医
心外脂肪组织
heart failure with preserved ejection fraction
"treating pathogenic accumulation with dissipation"
Chinese medicine
extracardiac adipose tissue
