摘要
目的:探讨疏血通注射液辅助治疗对老年缺血性脑卒中患者认知功能及转化生长因子-β_(1)(TGF-β_(1))、Smad同源物1(Smad1)的影响。方法:选择2021年4月—2023年4月昆山市锦溪人民医院收治的82例老年缺血性脑卒中患者作为研究对象。将随机分为观察组、对照组,各41例。对照组采用常规治疗,观察组在对照组基础上采用疏血通注射液辅助治疗。比较两组认知功能、TGF-β_(1)、Smad1、自理能力和神经功能、不良反应发生率。结果:治疗后,两组简易精神状态检查量表(MMSE)、蒙特利尔认知评估量表(MoCA)评分高于治疗前,临床痴呆评定量表(CDR)评分低于治疗前,且观察组MMSE、MoCA评分高于对照组,CDR评分低于对照组,差异有统计学意义(P<0.05)。治疗后,两组TGF-β_(1)低于治疗前,Smad1高于治疗前,且观察组TGF-β_(1)低于对照组,Smad1高于对照组,差异有统计学意义(P<0.05)。治疗后,两组日常生活能力量表(ADL)评分高于治疗前,美国国立卫生研究院卒中量表(NIHSS)评分低于治疗前,且观察组ADL评分高于对照组,NHISS评分低于对照组,差异有统计学意义(P<0.05)。观察组不良反应总发生率为7.32%,低于对照组的14.63%,但两组间比较,差异无统计学意义(P>0.05)。结论:疏血通注射液辅助治疗能够有效改善老年缺血性脑卒中患者的认知功能、TGF-β_(1)、Smad1,提高患者自理能力及神经功能,具有较高的安全性。
Objective:To investigate the effects of Shuxuetong Injection on cognitive function and transforming growth factor-β_(1)(TGF-β_(1)),Smad homolog 1(Smad1)in elderly patients with ischemic stroke.Method:A total of 82 elderly patients with ischemic stroke admitted to Kunshan Jinxi People's Hospital from April 2021 to April 2023 were selected as the study objects.They were randomly divided into observation group and control group,with 41 cases in each group.The control group was treated with routine treatment,and the observation group was treated with Shuxuetong Injection on the basis of control group.Cognitive function,TGF-β_(1),Smad1,selfcare ability,neurological function and incidence of adverse reactions were compared between the two groups.Result:After treatment,mini-mental state examination(MMSE)and Montreal cognitive assessment(MoCA)scores of the two groups were higher than those before treatment,and clinical dementia rating(CDR)scores were lower than those before treatment,and MMSE and MoCA scores of the observation group were higher than those of the control group,and CDR score was lower than that of the control group,the differences were statistically significant(P<0.05).After treatment,TGF-β_(1) was lower than that before treatment,Smad1 was higher than that before treatment,and TGF-β_(1) in observation group was lower than that in control group,Smad1 was higher than that in control group,the differences were statistically significant(P<0.05).After treatment,the activities of daily living(ADL)score of the two groups were higher than those before treatment,and the National Institute of Health stroke scale(NIHSS)score was lower than that before treatment,and the ADL score of the observation group was higher than that of the control group,and the NHISS score was lower than that of the control group,the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the observation group was 7.32%,which was lower than 14.63% in the control group,but there was no significant difference between the two groups(P>0.05).Conclusion:Shuxuetong Injection adjuvant therapy can effectively improve cognitive function,TGF-β_(1),Smad1 in elderly patients with ischemic stroke,improve patients'self-care ability and nervous function,and has a high safety.
作者
郑敏根
潘利亚
ZHENG Mingen;PAN Liya(Kunshan Jinxi People's Hospital,Kunshan 215324,China;不详)
出处
《中外医学研究》
2024年第7期18-21,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
