摘要
纳米制剂是目前药剂学领域的研究热点。传统中药“纳米化”为中药创新研究打开了新的大门,不仅改变了中药应用的“尺度”,更是拓展了中药治疗的范围。中药纳米制剂既能延续传统中药治疗“多靶点、多层次”的特点,又能改善活性成分口服生物利用度低、组织靶向性不足等问题。通过总结中药外泌体、碳点、纳米凝胶、聚合物胶束、自微乳和纳米脂质体相关研究,分析不同中药纳米制剂的作用特点,为创新中药研究提供思路。
Recently,nanoagents have become a hot topic in the field of pharmaceutics.The"nanotization"of Chinese medicine has opened up new avenues for the innovative research of Chinese medicine,not only changing the"scale"of its application but also expanding the scope of Chinese Medicine treatment.Nanoagents of Chinese medicine can maintain the characteristics of"multi-target and multi-level"of Chinese medicine treatment and improve low oral bioavailability and inadequate tissue targeting of active ingredients.By summarizing the relevant research on exosomes,carbon dots,nanogels,polymeric micelles,self-microemulsion,and nano-liposomes of Chinese medicine,and analyzing the functional characteristics of different nanoagents of Chinese medicine,this study provides ideas for innovative research on Chinese medicine.
作者
杨靖
柳炜佳
李英
曾莉
闫芳
YANG Jing;LIU Weijia;LI Ying;ZENG Li;YAN Fang(Department of Pharmacy,Chengdu Fifth People's Hospital(The Fifth People's Hospital of Chengdu University of Chinese Medicine),Chengdu,Sichuan 611130,China;Department of Rehabilitation Medicine,Chengdu Fifth People's Hospital(The Fifth People's Hospital of Chengdu University of Chinese Medicine),Chengdu,Sichuan 611130,China;Medical Research and Transformation Center,Chengdu Fifth People's Hospital(The Fifth People's Hospital of Chengdu University of Chinese Medicine),Chengdu,Sichuan 611130,China)
出处
《湖南中医药大学学报》
CAS
2024年第4期706-712,共7页
Journal of Hunan University of Chinese Medicine
基金
四川省医院协会青年药师科研专项资金项目(22007)
成都市医学科研课题(2023459)。
关键词
中药
纳米制剂
研究进展
构成
生物活性
Chinese medicine
nanoagent
research progress
composition
biological activity
