摘要
目的探讨幽门螺杆菌(Hp)阳性患者普通胃镜检查前使用盐酸达克罗宁胶浆联合链霉蛋白酶颗粒的应用效果。方法选取2023年1—7月在该院进行普通胃镜检查的100例Hp阳性患者作为研究对象,采用随机数字表法将其分为联合组和对照组,每组50例。联合组患者在进行胃镜检查前20 min内服用链霉蛋白酶颗粒,5 min内服用盐酸达克罗宁胶浆;对照组患者在胃镜检查前5 min内服用盐酸达克罗宁胶浆。比较两组患者胃黏膜清晰度量表评分、微小病灶检出情况、胃镜检查时间、药物不良反应发生情况、胃镜检查过程中恶心及呕吐严重程度。结果联合组患者胃底、胃体上部、胃体下部、胃窦胃黏膜清晰度量表评分均低于对照组,红斑、糜烂检出率均高于对照组(P<0.05)。联合组患者平均胃镜检查时间短于对照组(P<0.05)。两组患者药物不良反应总发生率比较,差异无统计学意义(P>0.05)。胃镜检查过程中,联合组患者恶心及呕吐严重程度轻于对照组(P<0.05)。结论Hp阳性患者普通胃镜检查前服用盐酸达克罗宁胶浆联合链霉蛋白酶颗粒可以显著改善胃镜检查的视野清晰度,提高微小病灶检出率,缩短检查时间,减轻胃镜检查过程中恶心及呕吐严重程度。
Objective To investigate the application effect of dyclonine hydrochloride mucilage combined with pronase granules in patients with Helicobacter pylori(Hp)positive before ordinary gastroscopy.Methods A total of 100 Hp positive patients who underwent ordinary gastroscopy in our hospital from January to July 2023 were selected as the research objects.According to the random number table method,they were divided into the combined group and the control group,with 50 cases in each group.Patients in the combined group took pronase granules within 20 minutes before gastroscopy and took dyclonine hydrochloride mucilage within 5 minutes before gastroscopy,patients in the control group took dyclonine hydrochloride mucilage within 5 minutes before gastroscopy.The score of gastric mucosa clarity scale,detection of small lesions,gastroscopy time,occurrence of adverse drug reactions,and severity of nausea and vomiting during gastroscopy were compared between the two groups.Results The scores of gastric fundus,upper gastric body,lower gastric body,antrum and gastric mucosa clarity scale in the combined group were lower than those in the control group,and the detection rates of erythema and erosion were higher than those in the control group(P<0.05).The average gastroscopy time of the combined group was shorter than that of the control group(P<0.05).There was no significant difference in the total incidence of adverse drug reactions between the two groups(P>0.05).During gastroscopy,the severity of nausea and vomiting in the combined group was lighter than that in the control group(P<0.05).Conclusion Dyclonine hydrochloride mucilage combined with pronase granules before gastroscopy in Hp positive patients can significantly improve t he visual field clarity of gastroscopy,improve the detection rate of small lesions,shorten the examination time and reduce the severity of nausea and vomiting during gastroscopy.
作者
张坤
卞孝平
杨春丽
张宁
张思宇
ZHANG Kun;BIAN Xiaoping;YANG Chunli;ZHANG Ning;ZHANG Siyu(Endoscopy Center,Zhengzhou Second People′s Hospital,Zhengzhou,Henan 450000,China)
出处
《检验医学与临床》
CAS
2024年第8期1133-1136,共4页
Laboratory Medicine and Clinic
