摘要
目的:观察和评价小承气汤加减方中药直肠滴注缓解阿片类药物相关性便秘(opioid-induced constipation,OIC)的临床优势。方法:采用随机数表法将80例阿片类药物相关性便秘患者分为试验组、对照组各40例,试验组和对照组分别采用小承气汤加减方中药直肠滴注及开塞露灌肠隔日1次,7天后比较肿瘤患者阿片类药物相关性便秘评估量表评分、中医证候评分、肠鸣音频率、KPS(Karnofsky)生活质量评分。结果:共79例(试验组40例、对照组39例)患者完成了研究。干预前两组患者一般资料及阿片类药物相关性便秘评估量表评分、中医证候评分、KPS评分、肠鸣音频率比较差异均无统计学意义(均P>0.05)。干预后试验组阿片类药物便秘总分评分(34.65±4.41)、排便规律维度(8.53±1.71)、排便结局维度(16.05±2.76)、中医证候评分(14.55±3.71)均低于对照组相应评分(37.21±4.72)、(9.54±1.98)、(17.38±2.98)、(16.38±2.48),差异有统计学意义(P<0.05);干预后试验组KPS评分(56.00±19.32)、肠鸣音频率(3.22±0.42)均高于对照组相应得分(47.69±15.47)、(2.50±0.42),差异有统计学意义(P<0.05);未见直肠滴注相关不良反应。结论:中药直肠滴注可有效改善OIC,提高治疗满意度及生活质量,安全有效。
Objective To observe and evaluate the clinical advantages of rectal instillation of modified Xiaochengqi Decoction in relieving opioid-induced constipation(OIC).Methods A total of 80patients with opioid-related constipation were divided into experimental group and control group by random number table method,with 40cases in each group.The experimental group and the control group were treated with rectal instillation of modified Xiaochengqi Decoction and enema of Kaisailu once every other day.After 7days,the opioid-related constipation assessment scale score,TCM syndrome efficacy,bowel sound frequency and KPS(Karnofsky)quality of life score of tumor patients were compared.Results There were no significant differences in general data,opioid-related constipation assessment scale score,TCM syndrome score,KPS score and bowel sound frequency between the two groups before intervention(all P>0.05).A total of 79patients(40in the experimental group and 39in the control group)completed the study.After intervention,the total score of opioid constipation(34.65±4.41),the dimension of defecation regularity(8.53±1.71),the dimension of defecation outcome(16.05±2.76)and the score of TCM syndrome(14.55±3.71)in the experimental group were lower than those in the control group(37.21±4.72),(9.54±1.98),(17.38±2.98),(16.38±2.48),the difference was statistically significant(P<0.05);the KPS score(56.00±19.32)and bowel sound frequency(3.22±0.42)in the experimental group were higher than those in the control group(47.69±15.47)and(2.50±0.42),and the differences were statistically significant(t=-2.589,7.519,all P>0.05);no adverse reactions related to rectal instillation of modified Xiaochengqi decoction were found.Conclusion Rectal instillation of traditional Chinese medicine can effectively improve OIC,improve treatment satisfaction and quality of life,safe and effective.
作者
李国敏
魏忠玲
钟印芹
龚杨
付艳丽
LI Guomin;WEI Zhonlin;ZHONG Yinqin(Sixth Clinical Medical College of Guangzhou University of Chinese Medicine Shenzhen Guangdong 518000,China;Department of Oncology,Shenzhen Hospital of Guangzhou University of Chinese Medicine,Shenzhen Guangdong 518000,China)
出处
《四川中医》
2024年第1期118-122,共5页
Journal of Sichuan of Traditional Chinese Medicine
基金
广东省中医药管理局科研项目(编号:20221330)。
关键词
癌痛
阿片类药物相关性便秘
生活质量
直肠滴注
Cancer pain
opioid-related constipation
quality of life
rectal instillation
