摘要
目的研究西藏地区藏族体检人群胃病患者幽门螺杆菌感染情况及血清胃功能水平。方法回顾性分析2022年10月至2023年10月在西藏阜康医院体检中心参加体检的藏族患者211例。对患者进行13C、14C尿素呼气试验来检测患者幽门螺杆菌(helicobactor pylori,Hp)的感染情况,应用酶联免疫吸附法对患者血清胃功能水平进行检测,以及应用胃镜技术观察患者胃黏膜情况。分别比较患不同胃部疾病患者Hp感染情况、各血清胃功能指标的差异。结果根据患者胃镜下黏膜情况将患者分为CAG组与CNG组。CAG组患者PGI、PGR水平低于CNG组患者水平,G-17水平高于CNG组水平;Hp感染组PGⅡ、G-17水平高于阴性组,PGR水平低于阴性组,差异均具有统计学意义(P<0.05);基于ROC曲线得出血清胃功能水平诊断CAG的最佳临界值。结论血清PGI、PGR、G-17水平及可作为拉萨地区藏族人群CAG与CNG筛查的血清学指标,当地人群血清胃功能指标与胃黏膜萎缩情况相关性显著,临床需开展针对性干预,降低胃部疾病发生风险,保障西藏人民健康。
Objective To study the infection of Helicobacter pylori and the serum gastric function level of patients with gastric diseases in Tibetan population.Methods A retrospective analysis was performed for 211 Tibetan patients who participated in physical examination at the Physical Examination Center of Fukang Hospital in Tibet from October 2022 to October 2023.13C and 14C urea breath tests were performed to detect the infection of Helicobacter pylori(Hp),enzyme-linked immunosorbent assay was used to detect the serum gastric function level of the patients,and gastroscopy was used to observe the gastric mucosa of the patients.The differences in Hp infection and serum gastric function indexes in patients with different gastric diseases were compared.Results The patients were divided into CAG group and CNG group according to their mucosal condition under gastroscopy.The levels of PGI and PGR in the CAG group were lower than those in the CNG group,while the levels of G-17 were higher than those in the CNG group.The levels of PGII and G-17 in the Hp infection group were higher than those in the negative group,while the PGR level was lower than that in the negative group,and the differences were statistically significant(P<0.05).Based on the ROC curve,the optimal cut-off value for the diagnosis of CAG was obtained.Conclusion Serum levels of PGI,PGR,and G-17 can be used as serological indicators for CAG and CNG screening in the Tibetan population in Lhasa.There is a significant correlation between serum gastric function indexes and gastric mucosal atrophy in the local population.Targeted interventions are needed to reduce the risk of gastric diseases and protect the health of the health of people in the region.
作者
李生隆
邢佳宝
达娃卓玛
央拉
多吉卓玛
任明辉
巴桑卓玛
Li Shenglong;Xing Jiabao;Dawa Zhuoma;Yang La;Duoji Zhuoma;Ren Minghui;Basang Zhuoma(Xizang Fukang Hospital,Lhasa 850000,China;Plateau Health Science Research Center,Xizang University,Lhasa 850000,China;Fuyang Vocational Technical College,Fuyang 236000,China)
出处
《西藏科技》
2024年第3期61-66,共6页
Xizang Science And Technology
基金
西藏大学研究生高水平人才培养计划项目(2021-GSP-S052)
国家自然科学基金项目(82241023)
中央支持地方部区合建综合学科创新平台建设项目(藏财预指〔2023〕1号)
2019年西藏自治区重点科技计划项目(08080002)
2023年西藏自治区科技计划“揭榜挂帅”专项(18080052)。
