摘要
cGAS-STING信号通路是一种新型的、重要的先天免疫信号通路,其被核酸物质激活,并与其他免疫应答相互作用,在炎症、感染、癌症等多种病理过程中发挥重要作用。近期研究发现cGAS-STING参与了各种与年龄相关的肌肉骨骼疾病的发生和发展,并对骨代谢产生影响。然而,在骨质疏松症(osteoporosis,OP)中确切的作用机制尚不清楚。因此,本文综述了cGAS-STING及其下游在OP中的作用机制,为开发OP新的治疗策略提供思路。
cGAS-STING signaling pathway is a novel and important innate immune signaling pathway,which is activated by nucleic acid substances and interacts with other immune responses,and plays an important role in various pathological processes such as inflammation,infection and cancer.It has recently been found that cGAS-STING is involved in the occurrence and development of various age-related musculoskeletal diseases and affects bone metabolism.However,the exact mechanism of action in osteoporosis(OP)remains unclear.Therefore,this paper summarizes the action mechanism of cGAS-STING and its downstream in OP,so as to provide new ideas for the treatment of OP.
作者
张忠文
赵瑞
齐雅茜
王薇
宋志靖
张浩令
ZHANG Zhongwen;ZHAO Rui;QI Yaqian;WANG Wei;SONG Zhijing;ZHANG Haoling(School of Public Health,Gansu University of Chinese Medicine,Lanzhou 730000,China;Clinical College of Chinese Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China;College of Acupuncture and Massage,Gansu University of Chinese Medicine,Lanzhou 730000,China;Key Laboratory of Dunhuang Medicine and Transformation,Ministry of Education,Lanzhou 730000,China;Institute of Advanced Medicine and Dentistry,Universiti Sains Malaysia,Penang 13200,Malaysia)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2024年第4期606-610,共5页
Chinese Journal of Osteoporosis
基金
国家自然科学基金(81960877)
甘肃省高等学校创新基金(2021A-076),甘肃省高等学校创新基金(2023A-088)
甘肃省科技计划(创新基地和人才计划)项目(21JR7RA561)
敦煌医学与转化教育部重点实验室开放基金项目(DHYX20-16)
甘肃省中医药研究中心专项开放课题(zyzx-2020-zx10)
甘肃省自然科学基金(21JR1RA267,22JR5RA582)
甘肃省教育科技创新项目(2022A-067)
甘肃省科技计划项目重点研发计划国际科技合作类(23YFWA0005)。
