摘要
目的:探讨联合检测血清糖类抗原72-4(CA72-4)、糖类抗原242(CA242)及胃泌素17(G-17)对胃癌的诊断价值。方法:选取上饶东信第五医院2022年2月—2023年5月收治的80例胃癌患者纳入研究组,另选取本院同期收治的80例胃良性病变患者纳入良性组,再选取本院同期体检的80例健康者纳入对照组。检测并对比三组血清CA72-4、CA242、G-17水平,分析联合检测血清CA72-4、CA242、G-17水平对胃癌的诊断价值;分析不同病理分期与血清CA72-4、CA242、G-17水平的关系。结果:研究组血清CA72-4、CA242、G-17水平均较良性组、对照组高,良性组各指标水平均较对照组高(P<0.05);受试者操作特征(ROC)曲线发现,血清CA72-4、CA242、G-17单独及联合检测胃癌的AUC均>0.70,均有一定诊断价值,其中联合检测诊断价值最高;不同病理分期胃癌患者中,Ⅳ期血清CA72-4、CA242、G-17水平最高,后依次为Ⅲ期、Ⅱ期、Ⅰ期(P<0.05);胃癌患者病理分期与血清CA72-4、CA242、G-17水平均呈正相关(P<0.05)。结论:血清CA72-4、CA242、G-17联合检测对胃癌有较高诊断价值,且与胃癌病理分期有关,考虑可将其作为胃癌诊断、预后评估重要指标。
Objective:To investigate the diagnostic value of combined detection of serum carbohydrate antigen 72-4(CA72-4),carbohydrate antigen 242(CA242)and gastrin 17(G-17)in gastric cancer.Method:A total of 80 patients with gastric cancer admitted to Shangrao Dongxin Fifth Hospital from February 2022 to May 2023 were included in the study group,80 patients with benign gastric lesions admitted to our hospital in the same period were included in the benign group,and 80 healthy people who underwent physical examination in the same time in our hospital were included in the control group.Serum CA72-4,CA242 and G-17 levels were detected and compared among the three groups.The diagnostic value of combined detection of serum CA72-4,CA242 and G-17 levels in gastric cancer were analyzed.The relationship between different pathological staging and serum CA72-4,CA242 and G-17 levels were analyzed.Result:The serum levels of CA72-4,CA242 and G-17 in the study group were higher than those in the benign group and the control group,and the levels of all indexes in the benign group were higher than those in the control group(P<0.05).The receiver operating characteristic(ROC)curve showed that the AUC of serum CA72-4,CA242,G-17 alone and combined detection of gastric cancer were all>0.70,which had certain diagnostic value,and the combined detection had the highest diagnostic value.The levels of serum CA72-4,CA242 and G-17 were the highest in stageⅣ,followed by stage Ⅲ,stage Ⅱ and stage Ⅰ(P<0.05).There were positive correlation between pathological staging and serum CA72-4,CA242 and G-17 levels in patients with gastric cancer(P<0.05).Conclusion:The combined detection of serum CA72-4,CA242 and G-17 has a high diagnostic value for gastric cancer,which is related to the pathological staging of gastric cancer,and can be considered as an important indicator for the diagnosis and prognosis evaluation of gastric cancer.
作者
李露
周鹏
邱玉琳
LI Lu;ZHOU Peng;QIU Yulin(Department of Clinical Laboratory,Shangrao Dongxin Fifth Hospital,Shangrao 334000,China;不详)
出处
《中国医学创新》
CAS
2024年第12期148-151,共4页
Medical Innovation of China
基金
上饶市科技计划一般项目(2022CZDX31)。
