摘要
胆汁酸可分为初级胆汁酸和次级胆汁酸,前者在肝细胞中直接合成,后者在肠道细菌分解后形成。肠道菌群种类繁多、应用广泛,与人体的各种功能和疾病密切相关。胆汁酸作为肠道菌群的主要代谢产物之一,二者之间存在着紧密的双向调控作用。目前已有研究表明,粪便胆汁酸水平与胃肠道功能变化之间具有显著的相关性。该文将从肠道中胆汁酸在腹泻与便秘症状下的变化问题出发,就粪便胆汁酸水平与儿童不同排便频次的关系作一综述,为进一步探索基于胆汁酸成分的不同代谢产物对排便频次的影响提供研究方向。
Bile acids can be categorized into primary bile acids,which are synthesized directly in liver cells,and secondary bile acids,which are formed after decomposition by intestinal bacteria.The intestinal flora is diverse and widely used,which is closely related to various functions and diseases in the human body.As one of the main metabolites of intestinal flora,bile acids have a close bidirectional regulation between them.Current research has shown a clear correlation between fecal bile acid levels and changes in gastrointestinal function.This paper will review the relationship between fecal bile acid levels and different defecation frequency in children from the perspective of changes in intestinal bile acids under diarrhea and constipation symptoms,and will provide a research direction for further exploration of the effects of different metabolites based on the composition of bile acids on defecation frequency.
作者
贺成慧
黄永坤
He Chenghui;Huang Yongkun(Department of Pediatrics,The First Affiliated Hospital of Kunming Medical University,Kunming 650032,China)
出处
《国际儿科学杂志》
2024年第3期164-167,共4页
International Journal of Pediatrics
基金
国家自然科学基金(81960102)。
关键词
儿童
粪便
胆汁酸
排便频次
Children
Feces
Bile acids
Defecation frequency
