摘要
过敏性哮喘是以慢性炎症、气道高反应为特征的复杂的、多基因相关的疾病。真菌、尘螨是过敏性哮喘最主要的吸入过敏原,并常以多种过敏原混合形式存在。近年来,遗传学研究证明多个基因与过敏性哮喘发作相关。该文主要对与尘螨、真菌所致过敏性哮喘相关的基因如解整合素-金属蛋白酶33(a disintegrin and metalloproteinase 33,ADAM33)、白介素4(interleukin-4,IL-4)、糖蛋白A为主的重复序列(glycoprotein A repetitions predominant,GARP)、Toll样受体3(toll like receptor 3,TLR3)、甘露糖结合凝集素2(mannose-binding lectin 2,MBL2)、趋化因子(CC基序)配体17[chemokine(C-C motif)ligand 17,CCL17]等进行综述。
Allergic asthma is a complex,polygenic disease characterized by chronic inflammation and airway hyperresponsiveness.Fungus and dust mites are the most important inhaled allergens of allergic asthma,and often exist in the form of mixed allergens.In recent years,genetic studies have shown that several genes are associated with allergic asthma attacks.This article reviews the studies on the genes related to allergic asthma caused by dust mites and fungus,such as a disintegrin and metalloproteinase 33(ADAM33),interleukin-4(IL-4),glycoprotein A repetitions predominant(GARP),toll like receptor 3(TLR3),mannose-binding lectin 2(MBL2),chemokine(C-C motif)ligand 17(CCL17)and other genes.
作者
高志莹
曹洛菲
马光增
苗瑜
耿玉婷
王金荣
Gao Zhiying;Cao Luofei;Ma Guangzeng;Miao Yu;Geng Yuting;Wang Jinrong(The Second Clinical College of Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Pediatric Respiratory Department,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,China)
出处
《国际儿科学杂志》
2024年第3期183-187,共5页
International Journal of Pediatrics
基金
山东省重点研发计划项目(2015GSF118036)
山东省自然科学基金(ZR2022MH254)。
关键词
过敏性哮喘
基因多态性
尘螨
真菌
Allergic asthma
Gene polymorphism
Dust mite
Fungus
