摘要
目的 探索急性髓细胞性白血病(AML)患者血小板输注效果的影响因素。方法 选取2021年12月至2022年12月于滨州医学院烟台附属医院进行血小板输注治疗的120例急性髓细胞性白血病患者为研究对象,其中输注无效组52例,输注有效组68例。通过统计学软件SPSS 23.0软件分析两组患者的一般性资料,并分析影响因素。结果 单因素分析结果显示,不同年龄、脾脏、活动性出血、血小板抗体、合并感染、输注次数及输注前后发热情况的AML患者血小板输注效果比较,差异有统计学意义(P<0.05)。多因素分析结果显示,年龄[18~<60岁组(OR=6.324,95%CI:1.1953~20.473,≥60岁组(OR=0.121,95%CI:0.019~0.757)]、脾脏(OR=2.850,95%CI:1.063~7.638)、合并感染(OR=9.994,95%CI:3.109~32.130)及输血次数(OR=5.053,95%CI:1.502~17.000)是影响AML患者血小板输注效果的相关因素(P<0.05)。结论 年龄、脾脏、合并感染及输血次数是影响AML患者血小板输注效果的危险因素,可针对具有相关临床特征的患者采取有针对性的预防措施,为急性髓系白血病患者提供更好的血小板输注效果。
Objective To explore the influencing factors of platelet transfusion efficacy in patients with acute myeloid leukemia(AML).Methods A total of 120 patients with AML who received platelet transfusion treatment in Yantai Affiliated Hospital of Binzhou Medical University from December 2021 to December 2022 were selected as the research objects,including 52 cases of ineffective transfusion group and 68 cases of effective transfusion group.The general data of the two groups were analyzed by statistical software SPSS 23.0,and the risk factors were analyzed.Results The results of univariate analysis showed that there were statistically significant differences in platelet transfusion efficacy among AML patients with different ages,spleen,active bleeding,platelet antibodies,co-infection,infusion times and fever before and after infusion(P<0.05).The results of multivariate analysis showed that age(18-<60 years old group[OR=6.324,95%CI:1.1953-20.473],≥60 years old group[OR=0.121,95%CI:0.019-0.757]),spleen(OR=2.850,95%CI:1.063-7.638),co-infection(OR=9.994,95%CI:3.109-32.130)and the number of blood transfusions(OR=5.053,95%CI:1.502-17.000)were the related factors affecting the platelet transfusion efficacy in patients with AML(P<0.05).Conclusion Age,spleen,co-infection and the number of blood transfusions are risk factors that affect the efficacy of platelet transfusion in AML patients.Targeted preventive measures can be taken for patients with related clinical characteristics to provide better platelet transfusion efficacy for AML patients.
作者
都新萍
宫淑文
杨青
DU Xinping;GONG Shuwen;YANG Qing(Department of Hematology,Yantai Affiliated Hospital of Binzhou Medical College,Shandong Province,Yantai264100,China;Department of Otolaryngology,Yantai Affiliated Hospital of Binzhou Medical College,Shandong Province,Yantai264100,China)
出处
《中国医药导报》
CAS
2024年第8期123-126,共4页
China Medical Herald
关键词
急性髓细胞性白血病
血小板输注
因素分析
疗效
Acute myeloid leukemia
Platelet transfusion
Factor analysis
Curative effect
