摘要
目的探究丁苯酞联合阿替普酶对缺血性脑血管病患者神经功能及颈动脉狭窄(Carotid Artery Stenosis,CAS)程度的影响。方法选取2020年1月—2023年1月南京市高淳中医院神经内科收治的46例缺血性脑血管病患者为研究对象,按照随机抽签法分为对照组(辅以阿替普酶治疗)、观察组(辅以丁苯酞、阿替普酶联合治疗),各23例,比较两组治疗总有效率、神经功能、CAS程度、症状性出血转化率。结果用药14 d后,观察组治疗总有效率(95.65%)较对照组(82.61%)高,但两组比较差异无统计学意义(χ^(2)=0.898,P>0.05)。观察组神经功能缺损评分低于对照组,斑块长径短于对照组,斑块数量少于对照组,颈动脉内膜中层厚度小于对照组,差异有统计学意义(P均<0.05)。两组症状性出血转化率比较,差异无统计学意义(P>0.05)。结论丁苯酞、阿替普酶的联合效果更优,减轻患者CAS程度、神经功能缺损,促进机体恢复后。
Objective To investigate the effects of butylphthalide combined with alteplase on neurological function and the degree of carotid artery stenosis(CAS)in patients with ischemic cerebrovascular disease.Methods 46 pa⁃tients with ischemic cerebrovascular disease admitted to the Department of Neurology of Nanjing Gaochun Traditional Chinese Medicine Hospital from January 2020 to January 2023 were selected as the study objects and were divided into control group(supplemented with alteplase)and observation group(supplemented with butylphthalide and al⁃teplase)according to random drawing method,with 23 cases in each group.The total effective rate,neurological func⁃tion,CAS degree and symptomatic bleeding conversion rate were compared between the two groups.Results After 14 days of treatment,the total effective rate of the observation group(95.65%)was higher than that of the control group(82.61%),but there was no significant difference between the two groups(χ^(2)=0.898,P>0.05).The neurological impair⁃ment score in the observation group was lower than that in the control group,the length and diameter of plaques were shorter than that in the control group,and the number of plaques was less than that in the control group,and the ca⁃rotid intima-media thickness were lower than that in the control group,the differences were statistically significant(all P<0.05).There was no significant difference in the conversion rate of symptomatic bleeding between the two groups(P>0.05).Conclusion The combined effect of butylphthalide and alteplase is more favorable,reducing the degree of CAS and neurological deficits of patients and promoting the recovery of the organism after.
作者
倪昌健
杨同慧
NI Changjian;YANG Tonghui(Department of Neurology,Nanjing Gaochun Hospital of Traditional Chinese Medicine,Nanjing,Jiangsu Province,211300 China)
出处
《系统医学》
2024年第5期102-105,共4页
Systems Medicine
关键词
缺血性脑血管病
丁苯酞
阿替普酶
神经功能
CAS程度
Ischemic cerebrovascular disease
Butylphthalide
Alteplase
Neurological function
CAS degree
