摘要
类风湿性关节炎(rheumatoid arthritis,RA)是一种自身免疫障碍性疾病,发病率高,好发于中年女性,严重影响患者的运动能力。目前,关乎其发病机制尚未完全明确,现有的治疗方案也仅停留在延缓病情、改善关节功能为目标。青藤碱是青风藤中的一种有效成分,具有抗炎、镇痛、免疫抑制、抗肿瘤等多种药理活性,其在治疗类风湿性关节炎方面颇有成效,主要通过缓解炎症、抑制滑膜增生、减轻骨破坏等途径,且联合用药的效果更佳。目前,市面上也出现了许多有关青藤碱的复方制剂,比如:除痹活络方、秦息痛片等,均表现出良好的抗RA作用,且不良反应较小。因此,基于青藤碱抗RA的相关研究,对青藤碱治疗类风湿性关节炎的作用机制及其复方制剂研究进行综述,以期为其以后的开发利用提供参考依据。
Rheumatoid arthritis(RA)is an autoimmune disease with a high incidence rate,which tends to occur in middle-aged women and seriously affects the motor ability of patients.At present,the pathogenesis of the disease is not fully understood,and existing treatment plans only focus on delaying the condition and improving joint function.Qingteng alkaloid is an effective ingredient in Qingfengteng,which has various pharmacological activities such as anti-inflammatory,analgesic,immunosuppressive,anti-tumor,etc.It is quite effective in the treatment of rheumatoid arthritis,mainly by alleviating inflammation,inhibiting periosteal proliferation,reducing bone damage,and the combined use of drugs has a better effect.Nowadays,there are also many compound preparations related to sinomenine on the market,such as Qubi Huoluorecipe,Qinxitong tablet,etc.,all of which have shown good anti RA effects with minimal adverse reactions.Therefore,based on the relevant research on the anti RA effect of sinomenine,this article reviews the mechanism of action and compound preparations of sinomenine in the treatment of rheumatoid arthritis,in order to provide reference for its future development and utilization.
作者
胡剑威
丁超
吴莹
张玉莹
龚传明
张东东
王薇
HU Jianwei;DING Chao;WU Ying;ZHANG Yuying;GONG Chuanming;ZHANG Dongdong;WANG Wei(Liangzhou Hospital in Wuwei City,Gansu Wuwei 733000,China;School of Pharmacy,Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712046,China)
出处
《陕西中医药大学学报》
2024年第3期1-7,共7页
Journal of Shaanxi University of Chinese Medicine
基金
国家自然科学基金项目(82104368)
陕西中医药大学创新团队项目(2023-CXTD-05)。
关键词
青风藤
青藤碱
类风湿关节炎
作用机制
Qingfengteng
Qingteng alkaloid
Rheumatoid arthritis
Mechanism of action
