摘要
目的:探讨联合应用左西孟旦与多巴酚丁胺治疗急性心力衰竭(AHF)的效果。方法:选取2022年1月—2023年7月在莆田学院附属医院接受治疗的82例AHF患者作为研究对象,使用随机数表法将其分为常规组(n=41)与治疗组(n=41)。常规组给予多巴酚丁胺治疗,在常规组基础上治疗组加用左西孟旦治疗。比较两组临床疗效、心功能[每搏输出量(SV)、左心室射血分数(LVEF)、心脏指数(CI)]、炎症反应[超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]及不良反应。结果:与常规组比较,治疗组总有效率更高,差异有统计学意义(P<0.05);与治疗前比较,两组治疗后SV、LVEF、CI升高,且治疗组上述指标较常规组更高,差异有统计学意义(P<0.05);与治疗前比较,两组治疗后血清hs-CRP、IL-6、TNF-α水平下降,且治疗组上述指标较常规组更低,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:左西孟旦联合多巴酚丁胺治疗AHF效果确切,可降低炎症反应,减轻心肌损伤,改善心功能,且安全性较好。
Objective:To investigate the effect of combined use of Levosimendan and Dobutamine in the treatment of patients with acute heart failure(AHF).Method:A total of 82 patients with AHF who admitted to Putian University Affiliated Hospital from January 2022 to July 2023 were selected as the study objects,and they were randomly divided into the conventional group(n=41)and the treatment group(n=41)using a random number table method.The conventional group was treated with Dobutamine,and in addition to the conventional group,the treatment group was treated with Levosimendan.The clinical efficacy,cardiac function[stroke output(SV),left ventricular ejection fraction(LVEF),cardiac index(CI)],inflammatory response[high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)]and adverse reactions between two groups were compared.Result:Compared with the conventional group,the total effective rate of the treatment group was higher,and the difference was statistically significant(P<0.05);compared with before treatment,the SV,LVEF and CI in two groups after treatment were higher,and the above indicators in the treatment group were higher than those in the conventional group,the differences were statistically significant(P<0.05);compared with before treatment,the levels of serum hs-CRP,IL-6 and TNF-αin two groups after treatment decreased,and the above indicators in the treatment group were lower than those in the control group,the differences were statistically significant(P<0.05);there was no statistically significant difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion:Levosimendan combined with Dobutamine in the treatment of AHF is effective,it can reduce inflammatory reactions,improve cardiac function,and has good safety.
作者
黄珊娇
HUANG Shanjiao(Putian University Affiliated Hospital,Putian 351100,China)
出处
《中外医学研究》
2024年第11期30-33,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
