摘要
目的 探讨经尿道膀胱肿瘤电切术治疗膀胱癌的临床疗效及对患者预后的影响。方法 将2015年1月—2022年1月在本院治疗的80例浅表性膀胱癌患者随机分为两组,对照组使用传统开放性膀胱部分切除术,观察组使用经尿道膀胱肿瘤电切术(TURBT),对比两组的各项手术指标、并发症、血清肿瘤标志物、生活质量及复发情况。结果 观察组手术时间、术中出血量、留置导尿管时间、住院时间均少于对照组(P<0.05);观察组尿道狭窄、膀胱穿孔、膀胱痉挛、闭孔神经反射等并发症发生率低于对照组(P<0.05);观察组术后6个月的CEA、CA125、BTA、VEGF水平均低于对照组(P<0.05);观察组术后1年复发率低于对照组,术后1年的EORTC QLQ-C30评分高于对照组(P<0.05)。结论 TURBT治疗膀胱癌的临床疗效显著,创伤小,肿瘤根治效果好,术后可明显降低肿瘤标志物水平,减少远期复发,提高生存质量。
Objective To investigate clinical effect of transurethral resection of bladder tumor in treatment of bladder cancer and its effect on prognosis of patients.Methods The paper chose 80patients with superficial bladder cancer in our hospital from January 2015 to January 2022,and divided them into two groups randomly.Control group was treated with traditional open partial cystectomy,and observation group with transurethral resection of bladder tumor(TURBT).Surgical indicators,complications,serum tumor markers,life quality,and recurrence were compared between two groups.Results Observation group had shorter surgical time,intraoperative blood loss,indwelling catheter time,and hospital stay than control group(P< 0.05).Incidence of complications including urethral stricture,bladder perforation,bladder spasm,and obturator nerve reflex in observation group was lower than control group(P<0.05).Levels of CEA,CA12-5,BTA,and VEGF in observation group were lower than control group at 6 months after surgery(P<0.05).One-year postoperative recurrence rate of observation group was lower than control group,and EORTC QLQ-C30 scores were higher than control group one year after surgery(P<0.05).Conclusion TURBT is effective in treatment of bladder cancer with little trauma and good curative effect,can reduce level of tumor markers,reduce long-term recurrence and improve life quality after operation significantly.
作者
宋涛
庞栋
方洁
SONG Tao;PANG Dong;FANG Jie(Urology Department,Beijing Mentougou District Hospital/Capital Medical University Mentougou Teaching Hospital,Beijing 102300)
出处
《智慧健康》
2024年第7期97-100,共4页
Smart Healthcare
关键词
膀胱癌
经尿道膀胱肿瘤电切术
疗效
预后
Bladder cancer
Transurethral resection of bladder tumors
Curative effect
Prognosis
