摘要
目的:探究血浆Klotho浓度与睡眠障碍之间的相关性。方法:本研究分析了2007至2014年间美国国家健康与营养调查(NHANES)收集的9394名参与者的数据。通过评估临床基线特征,并构建三个多元lo⁃gistic回归模型,旨在探讨血浆Klotho浓度与睡眠障碍之间的关系,并通过亚组分析来检验这种相关性是否受到年龄、性别和种族的影响。结果:在纳入的9394名参与者中,有1041名被诊断为睡眠障碍。经过完全校正的多元logistic回归模型显示,较高的血浆Klotho浓度对于预防睡眠障碍具有显著的保护作用(OR=0.61,P<0.05)。此外,血浆Klotho浓度较高的群体发生睡眠障碍的风险较低(OR=0.84,P<0.05)。亚组分析表明,男性似乎更受Klotho的保护效应的影响。结论:较高的血浆Klotho水平与较低的睡眠障碍发生率相关。
Objective:To investigate the association between plasma Klotho levels and the occurrence of sleep dis⁃orders.Methods:Data from 9,394 participants collected during the 2007 to 2014 National Health and Nutrition Exami⁃nation Survey(NHANES)were analyzed in this study.By assessing clinical baseline characteristics and constructing three multivariate logistic regression models,the study sought to explore the relationship between plasma Klotho concen⁃trations and sleep disorders,and to examine whether this association was influenced by age,gender,and ethnicity through subgroup analysis.Results:Among the 9,394 participants included,1,041 were diagnosed with sleep disor⁃ders.Fully adjusted multivariate logistic regression models revealed a significant protective effect of higher plasma Klotho levels against sleep disorders(OR=0.61,P<0.05).Additionally,individuals with higher plasma Klotho concentrations were found to have a lower risk of developing sleep disorders(OR=0.84,P<0.05).Subgroup analysis indicated that males might be more susceptible to the protective effects of Klotho.Conclusion:Higher levels of plasma Klotho are asso⁃ciated with a lower incidence of sleep disorders.
作者
宁致远
唐亚梅
NING Zhi-yuan;TANG Ya-mei(Department of Neurology,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou,510120)
出处
《岭南急诊医学杂志》
2024年第2期128-132,共5页
Lingnan Journal of Emergency Medicine
