摘要
目的 分析布拉氏酵母菌联合更昔洛韦治疗巨细胞病毒(CMV)感染相关性溃疡性结肠炎(UC)的临床疗效。方法 60例巨细胞病毒感染相关性溃疡性结肠炎患者为研究对象,将患者的入院序列数作为基础,使用随机数字分组的方式将患者分为对照组与观察组,每组30例。对照组患者采用更昔洛韦治疗,观察组患者采用布拉氏酵母菌联合更昔洛韦治疗。比较两组患者治疗前后炎症因子[肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)]水平,临床症状好转时间及巨细胞病毒感染转阴率,临床治疗效果。结果 治疗后,观察组TNF-α(15.23±2.19)pg/ml、IL-6(145.93±11.02)pg/ml低于对照组的(25.32±2.63)、(198.72±11.51)pg/ml,差异具有统计学意义(P<0.05)。观察组患者的腹泻消失时间(6.17±1.58)d、血便消失时间(4.32±1.35)d短于对照组的(9.87±1.69)、(7.21±1.86)d,巨细胞病毒感染转阴率93.3%高于对照组的63.3%,差异具有统计学意义(P<0.05)。观察组患者的总有效率96.7%高于对照组的80.0%,差异具有统计学意义(P<0.05)。结论 在对巨细胞病毒感染相关性溃疡性结肠炎患者进行治疗的过程中,采用布拉氏酵母菌联合更昔洛韦进行治疗,能够改善患者的炎症因子水平、临床症状好转时间与临床治疗效果,值得推广与应用。
Objective To analyze the clinical efficacy of Saccharomyces boulardii in combination with ganciclovir in the treatment of ulcerative colitis(UC)associated with cytomegalovirus(CMV)infection.Methods 60 cases of UC associated with CMV infection were studied and divided into a control group and an observation group by random number grouping,with 30 cases in each group.Patients in the control group were treated with ganciclovir,and patients in the observation group were treated with Saccharomyces bralardii combined with ganciclovir.The levels of inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)]before and after treatment,the time of improvement of clinical symptoms and the conversion rate of cytomegalovirus infection were compared between the two groups.Results After treatment,the observation group had TNF-αof(15.23±2.19)pg/ml and IL-6 of(145.93±11.02)pg/ml,which were lower than(25.32±2.63)and(198.72±11.51)pg/ml in the control group,and the difference was statistically significant(P<0.05).The disappearance time of diarrhea and blood stool were(6.17±1.58)and(4.32±1.35)d in the observation group,which were shorter than(9.87±1.69)and(7.21±1.86)d in the control group;the observation group had higher negative-conversion rate of cytomegalovirus infection of 93.3%than 63.3%in the control group;the difference was statistically significant(P<0.05).The total effective rate of 96.7%in the observation group was higher than 80.0%in the control group,and the difference was statistically significant(P<0.05).Conclusion In the treatment of ulcerative colitis associated with cytomegalovirus infection,the use of Saccharomyces boulardii combined with ganciclovir can improve the level of inflammatory factors,clinical symptom improvement time and clinical treatment effect,which is worthy of promotion and application.
作者
熊苗
XIONG Miao(Shanghai Hospital of Wanzhou District,Chongqing 404120,China)
出处
《中国实用医药》
2024年第8期121-124,共4页
China Practical Medicine
