摘要
目的 探讨血清富含半胱氨酸蛋白61(CYR61)、心型脂肪酸结合蛋白(H-FABP)在新生儿急性呼吸窘迫综合征诊断中的临床价值。方法 选择2020年11月至2022年11月在该院接受治疗的105例急性呼吸窘迫综合征患儿作为研究组,并分为轻度组(42例)、中度组(35例)、重度组(28例),另选择同期60例健康新生儿作为对照组。所有纳入对象入院后检测血清CYR61、H-FABP水平,并进行比较。采用受试者工作特征(ROC)曲线和曲线下面积(AUC)评估血清CYR61、H-FABP对新生儿急性呼吸窘迫综合征的诊断价值,采用多因素Logistic回归分析影响新生儿急性呼吸窘迫综合征发生的相关因素。结果 研究组血清CYR61、H-FABP水平均高于对照组,差异有统计学意义(P<0.05);重度组患儿血清CYR61、H-FABP水平均高于中度组、轻度组(重度组>中度组>轻度组),差异有统计学意义(P<0.05)。ROC曲线分析显示,血清CYR61评估新生儿急性呼吸窘迫综合征的AUC为0.843(95%CI:0.824~0.893);血清H-FABP评估新生儿急性呼吸窘迫综合征的AUC为0.864(95%CI:0.814~0.914);二者联合评估新生儿急性呼吸窘迫综合征的AUC为0.925(95%CI:0.875~0.975)。多因素Logistic逐步回归分析显示,血清CYR61(OR=3.050,95%CI:1.738~5.352)、H-FABP(OR=3.773,95%CI:1.845~7.717)、C反应蛋白(OR=2.349,95%CI:1.584~3.483)及氧合指数(OR=1.944,95%CI:1.444~2.619)均为影响新生儿急性呼吸窘迫综合征发生的危险因素(P<0.05)。结论 血清CYR61、H-FABP在新生儿急性呼吸窘迫综合征中均升高,并与疾病严重程度密切有关,有望作为早期诊断新生儿急性呼吸窘迫综合征发生的有效生物学指标。
Objective To explore the clinical value of serum cysteine-rich protein 61(CYR61)and cardiac fatty acid-binding protein(H-FABP)in the diagnosis of neonatal acute respiratory distress syndrome.Methods A total of 105 children with acute respiratory distress syndrome who received treatment in the hospital from November 2020 to November 2022 were selected as the study group,and divided into mild group(42 cases),moderate group(35 cases)and severe group(28 cases).In addition,60 healthy newborns in the same period were selected as the control group.Serum CYR61 and H-FABP levels were detected and compared in all subjects after admission.Receiver operating characteristic(ROC)curve and area under curve(AUC)were used to evaluate the diagnostic value of serum CYR61 and H-FABP in neonatal acute respiratory distress syndrome.The related factors affecting the occurrence of neonatal acute respiratory distress syndrome were explored by multivariate Logistic regression.Results The levels of serum CYR61 and H-FABP in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).Serum CYR61 and H-FABP levels in severe group were higher than those in moderate and mild groups(severe group>moderate group>mild group),and the differences were statistically significant(P<0.05).ROC curve analysis showed that the AUC of serum CYR61 for neonatal acute respiratory distress syndrome was 0.843(95%CI:0.824-0.893).The AUC of serum H-FABP for neonatal acute respiratory distress syndrome was 0.864(95%CI:0.814-0.914).The AUC of the combined detection for neonatal acute respiratory distress syndrome were 0.925(95%CI:0.875-0.975).Multivariate Logistic stepwise regression analysis showed that serum CYR61(OR=3.050,95%CI:1.738-5.352),H-FABP(OR=3.773,95%CI:1.845-7.717),C-reactive protein(OR=2.349,95%CI:1.584-3.483)and oxygenation index(OR=1.944,95%CI:1.444-2.619)were risk factors for neonatal acute respiratory distress syndrome(P<0.05).Conclusion Serum CYR61 and H-FABP are both elevated in neonatal acute respiratory distress syndrome,and are closely related to the severity of the disease,which are expected to be effective biological indexes for early diagnosis of neonatal acute respiratory distress syndrome.
作者
黄佳骏
宋磊
朱美君
HUANG Jiajun;SONG Lei;ZHU Meijun(Department of Pediatrics,the Second Affiliated Hospital of Nantong University(the First People′s Hospital of Nantong),Nantong,Jiangsu 226000,China)
出处
《国际检验医学杂志》
CAS
2024年第10期1203-1206,1211,共5页
International Journal of Laboratory Medicine
基金
南通市基础科学研究和社会民生科技计划项目(MSZ2022020)。
