摘要
目的:维生素D缺乏性佝偻病是以骨骼病变为主的慢性营养缺乏性疾病,主要特征是形成骨基质钙化障碍,常伴有反复呼吸道感染、肌肉松弛、食欲降低、便溏、囟门迟闭、夜惊、出汗等症状,若不及时进行治疗,将会发生骨骼异常,严重影响患儿的生长发育。西医目前治疗该病多通过补充维生素D促进钙磷吸收,但长期连续口服维生素D存在一定的不良反应,可导致软组织钙沉着、肾功能损害。近年来中医中药在防治维生素D缺乏性佝偻病中表现出了良好的技术优势,本研究主要观察健脾补肺法联合西药治疗肺脾气虚型维生素D缺乏性佝偻病疗效。方法:将90例患儿随机分为治疗组45例、对照组45例。对照组予以骨化三醇及葡萄糖酸钙,治疗组在对照组基础上口服以健脾益气、补肺固表为基础的中药颗粒剂,服药3个月后,观察两组的综合疗效及比较治疗前后症状(精神、毛发情况、食量状况、出汗、面色、大便性状、患感冒次数)的中医证候总积分。结果:治疗组总有效率为95.24%(40/42),对照组总有效率为78.05%(32/41),两组差异有统计学意义(P <0.05);治疗后两组中医证候总积分比较,差异有统计学意义(P <0.05)。结论:健脾补肺法联合西药治疗肺脾气虚型维生素D缺乏性佝偻病疗效确切,可显著降低患者中医证候评分,值得临床推广。
Objective:Vitamin D deficiency rickets is a chronic nutritional deficiency disease based on bone lesions,which is mainly characterized by the formation of bone matrix calcification disorder,and is often accompanied by repeated respiratory infections,muscular flaccidity,decreased appetite,loose stool,delayed closure of the fontanelle,night terrors,sweating and other symptoms.If it is not timely treated,bone abnormalities will occur,which will seriously affect the growth and development of children.At present,Western medicine usually supplements vitamin D to promote calcium and phosphorus absorption,but long-term continuous oral administration of vitamin D has certain adverse reactions,which can lead to chondrocalcinosis and renal function damage.In recent years,TCM has shown good technical advantages in the prevention and treatment of vitamin D deficiency rickets.This study mainly observes the therapeutic effect of the strengthening the spleen and tonifying the lung method combined with Western medicine in the treatment of vitamin D deficiency rickets of lung and spleen Qi(气)deficiency type.Methods:A total of 90 children were randomly divided into the treatment group(45 cases)and the control group(45 cases).The control group was given calcitriol and calcium gluconate,and the treatment group was given oral TCM medicine granules based on invigorating spleen and tonifying Qi,and supplementing lung and strengthening the exterior.After taking the medicine for 3 months,the comprehensive curative effect in the two groups was observed,and the total scores of TCM syndrome,(mental condition,hair condition,food intake condition,sweating,complexion,stool characteristics,and number of colds)before and after treatment were compared.Results:The total effective rate was 95.24%in the treatment group and 78.05%in the control group,and the difference was significant(P<0.05).There was significant difference in the total score of TCM syndrome between the two groups after treatment(P<0.05).Conclusion:The method of invigorating spleen and tonifying lung combined with Western medicine has a good clinical effect on vitamin D deficiency rickets of lung and spleen Qi deficiency type.It can significantly reduce the TCM syndrome score of patients and is worthy of clinical promotion.
作者
王晓丽
汪斌
徐天鹏
窦世琮
张宏山
严文娟
WANG Xiaoli;WANG Bin;XU Tianpeng;DOU Shicong;ZHANG Hongshan;YAN Wenjuan
出处
《中医临床研究》
2024年第6期126-129,共4页
Clinical Journal Of Chinese Medicine
基金
武威市市列科技计划项目(WW1901105)。
关键词
维生素D缺乏性佝偻病
肺脾气虚型
健脾补肺法
临床研究
Vitamin D deficiency rickets
Deficiency of lung and spleen Qi
Invigorating spleen and tonifying lung method
Clinical research
