摘要
在规模化养殖模式下,畜禽在生长过程中会不可避免地面对各种不利因素,导致体内产生氧化应激,严重影响其生长发育。畜禽体内存在多种抗氧化因子来应对氧化应激。其中,帕金森相关蛋白7(Parkinson’s Disease-Associated Protein 7,PARK7)基因是细胞氧化应激中重要的调控因子之一。PARK7通过自身半胱氨酸的氧化水平感受氧化应激信号,并通过Nrf2、ERK1/2和PI3K/Akt等途径促进抗氧化酶的生成,提高细胞的抗氧化能力,从而减轻氧化应激引起的损伤。本文对PARK7基因在氧化应激中的调控作用和通路进行综述,将有助于畜禽氧化应激的调节机制研究。
Under the large-scale breeding mode,the livestock inevitably faces various adverse factors in the growth process,which leads to oxidative stress in the body and seriously affects their growth and development.There are a variety of antioxidant factors in livestock and poultry to cope with oxidative stress.Among them,Parkinson's disease associated protein 7(PARK7)gene is one of the important regulators in cellular oxidative stress.PARK7 senses oxidative stress signals through the oxidation level of its own cysteine,and promotes the generation of antioxidant enzymes through Nrf2,erk1/2,and pi3k/akt pathways to improve the antioxidant capacity of cells,thereby alleviating the damage caused by oxidative stress.
作者
樊庆灿
王倩倩
杨虎
郑路程
胡威
FAN Qingcan;WANG Qianqian;YANG Hu;ZHENG Lucheng;HU Wei(College of Life Science and Resources and Environment,Yichun University,Jiangxi Yichun 336000,China;College of Animal Medicine,Gansu Agricultural University,Gansu Lanzhou 730070,China)
出处
《中国畜牧杂志》
CAS
CSCD
北大核心
2024年第5期8-12,共5页
Chinese Journal of Animal Science
基金
江西省教育厅科学技术项目(GJJ211628)
宜春学院2021年第二批校级大学生创新创业训练计划项目(447)。
