摘要
目的:探讨薄层液基细胞学(TCT)联合人乳头状瘤病毒(HPV)检测在宫颈癌筛查中的应用价值,分析宫颈癌与阴道感染的关系。方法:收集2022年7月-2023年7月本中心行宫颈病变筛查的483名女性临床资料,纳入对象均行TCT、HPV检测,依据病理诊断结果分为非宫颈癌组(n=467)和宫颈癌(n=16),受试者工作特征曲线(ROC)分析TCT、HPV检测筛查宫颈癌价值;比较两组阴道感染率、阴道微生态情况。结果:以病理结果为依据,诊断宫颈癌TCT检测准确率为92.3%,HPV检测准确率为92.6%,2项联合检测准确率为98.1%;ROC分析,2项联合检测诊断宫颈癌的曲线下面积(0.953)高于TCT(0.777)、HPV(0.808),联合检测诊断特异度(96.8%)和敏感度(93.8%)更高(P<0.05);宫颈癌组阴道感染率(93.8%)高于非宫颈癌组(29.1%),过氧化氢(56.3%)、乳杆菌(50.0%)阳性率高于非宫颈癌组(31,1%、21.0%),唾液酸苷酶(6.3%)、白细胞酯酶(43.8%)阳性率低于非宫颈癌组(28.9%、75.4%)(均P<0.05)。结论:TCT联合HPV检测筛查宫颈癌价值较高,宫颈癌患者阴道感染率升高,阴道微生态发生变化,临床需多加关注。
Objective:To investigate the application value of thin layer liquid cytology test(TCT)combined with human papillomavirus(HPV)detection for screening the cervical cancer,and to study the correlation between the cervical cancer of women and their vaginal infection.Methods:The clinical data of 483women who underwent cervical lesion screening from July 2022to July2023were collected in this study,and these women were given TCT and HPV detection.According to the pathological diagnosis results,the women were divided into 467women without cervical cancer in control group and 16women with cervical cancer in observation group.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of TCT and HPV detection for screening the cervical cancer.The incidence of vaginal infection and the vaginal microecology of the women were compared between the two groups.Results:Based on the pathological results,the accuracy of TCT,HPV and the combined detection of TCT and HPV of the patients for diagnosing their cervical cancer were 92.3%,92.6%and 98.1%,respectively.ROC analysis showed that the area under the curve of the combined TCT and HPV detection for diagnosing the cervical cancer was 0.953,which was significantly higher than that(0.777)of TCT and that(0.808)of HPV detection.The specificity and the sensitivity of the combined TCT and HPV detection for diagnosing the cervical cancer were 96.8%and 93.8%,and which were significantly higher(P<0.05).The vaginal infection rate(93.8%),and the positive rates of hydrogen peroxide(56.3%)and lactobacillus5349(50.0%)of the women in the observation group were significantly higher than those(29.1%,31.1%and 21.0%)of the women in the control group.The positive rates of sialidase(6.3%)and leukocyte esterase(43.8%)of the women in the observation group were significantly lower than those(28.9%and 75.4%)of the women in the control group(all P<0.05).Conclusion:The combined TCT and HPV detection for screening the cervical cancer has higher application value.The vaginal infection rate of the women with cervical cancer increases,and the vaginal microecology of the women with cervical cancer has changed,which needs more clinical attention.
作者
史琴波
袁芳玲
SHI Qinbo;YUAN Fangling(Yinzhou District Baizhang Street Community Health Service Center,Ningbo,Zhejiang Province,315040;Zhoushan Hospital,Zhoushan,Zhejiang Province)
出处
《中国计划生育学杂志》
2024年第5期1158-1161,共4页
Chinese Journal of Family Planning
关键词
宫颈癌
薄层液基细胞学
人乳头状瘤病毒
筛查
阴道感染
阴道微生态
Cervical cancer
Thin layer liquid cytology test
Human papillomavirus
Screening
Vaginal infection
Vaginal microecology
