摘要
目的:探讨粪菌移植治疗交替型肠易激综合征(IBS-M)患者的短期疗效和安全性。方法:选取2021年4月至2022年12月,江门市人民医院消化内科收治的IBS-M患者40例,随机分为观察组和对照组,每组各20例。对照组给予双歧杆菌四联活菌治疗,观察组采用粪菌移植治疗。比较2组的短期疗效,包括肠易激综合征严重程度(IBS-SSS)评分、肠易激综合征生活质量(IBS-QOL)评分、胃肠道症状分级(GSRS)评分、肠道菌群多样性(Chao1和Shannon指数)和安全性。结果:与治疗前相比,治疗后8周和3个月的IBS-SSS、GSRS评分均明显降低,IBS-QOL评分升高,且观察组优于对照组(P<0.05)。观察组治疗后Chao1和Shannon指数均高于对照组,且治疗后3个月Chao1和Shannon指数均高于治疗后8周(P<0.05)。2组在安全性评估方面比较,差异无统计学意义(P>0.05)。结论:粪菌移植治疗交替型肠易激综合征患者可提高短期临床疗效,增加肠道菌群的多样性,且安全性良好。
Objective To investigate the short-term efficacy and safety of fecal microbiota transplantation in the treatment of patients with mixed type of irritable bowel syndrome(IBS-M).Methods Total 40 patients with IBS-M admitted to the Department of Gastroenterology of Jiangmen People's Hospital from April 2021 to December 2022 were randomly divided into the observation group and the control group,with 20 patients in each group.The control group was treated with bifidobacterium quadruple viable bacteria while the observation group was treated with fecal microbiota transplantation.The short-term efficacy of the two groups was compared,including IBS severity(IBS-SSS)score,IBS quality of life(IBS-QOL)score,gastrointestinal symptom rating scale(GSRS)score,intestinal flora diversity(Chao1 and Shannon indexes)and safety.Results At 8 weeks and 3 months after treatment,IBS-SSS and GSRS scores were significantly decreased,IBS-QOL scores were increased,and all the scores were better in the observation group than in the control group(P<0.05).Chao1 and Shannon indexes in the observation group were higher than those in the control group after treatment,and indexes in the observation group at 3 months after treatment were higher than those at 8 weeks after treatment(P<0.05).There was no significant difference in safety assessment between the two groups(P>0.05).Conclusion Fecal microbiota transplantation can improve the short-term clinical efficacy and increase the diversity of intestinal flora in IBS-M patients with good safety.
作者
钟碧莹
龚栋耀
曾凤
ZHONG Bi-ying;GONG Dong-yao;ZENG Feng(Department of Gastroenterology,Jiangmen People's Hospital,Jiangmen,Guangdong 529000)
出处
《中国肛肠病杂志》
2024年第3期12-15,共4页
Chinese Journal of Coloproctology
基金
江门市科技计划项目(2021YL02016)。
关键词
交替型肠易激综合征
粪菌移植
短期疗效
安全性
Mixed type of irritable bowel syndrome
Fecal microbiota transplantation
Short-term efficacy
Safety
