摘要
目的 观察归黄固齿方治疗慢性牙周炎疗效及对龈沟液白细胞介素-1β(IL-1β)、基质金属蛋白酶-13(MMP-13)水平的影响。方法 将我院90例慢性牙周炎(胃火炽盛证)患者按照随机数表法分为对照组与治疗组各45例。对照组在基础治疗上采用罗红霉素片、替硝唑片治疗,治疗组在对照组治疗基础上采用归黄固齿方辅助治疗。比较两组临床疗效及治疗前后中医证候积分,龈沟液实验室指标IL-1β、MMP-13,牙周临床指标牙周袋深度(PD)、龈沟出血指数(SBI)、牙龈指数(GI),骨代谢指标碱性磷酸酶(ALP)、骨钙素(OC)、Ⅰ型前胶原N端前肽(PINP)。结果 治疗后,治疗组总有效率高于对照组(P<0.05);两组中医证候积分、IL-1β、MMP-13、PD、SBI、GI、ALP、OC均较治疗前降低,PINP较治疗前升高,治疗组上述指标与对照组比较差异有统计学意义(P<0.05)。结论 归黄固齿方治疗慢性牙周炎患者疗效良好,能够降低IL-1β、MMP-13水平,改善牙周健康和骨代谢指标,临床推荐应用。
Objective To observe the therapeutic effect of Guihuang Guchi Prescription as adjuvant therapy on chronic periodontitis,and its influence on interleukin-1β(IL-1β)and matrix metalloproteinase-13(MMP-13)levels in gingival crevicular fluid.Methods Ninety patients with chronic periodontitis(stomach excess-heat syndrome)were divided into conventional treatment group and adjuvant therapy group,with 45 cases in each group.Conventional treatment group was treated with ro-xithromycin and tinidazole on the basis of basic treatment,while adjuvant therapy group was treated with Guihuang Guchi Prescription on the basis of conventional treatment group.The two groups were compared in terms of clinical effects,TCM syndrome scores,laboratory indicators IL-1βand MMP-13 in gingival crevicular fluid,periodontal clinical indicators periodontal pocket depth(PD),sulcus bleeding index(SBI)and gingival index(GI),and bone metabolism indicators alkaline phosphatase(ALP),osteocalcin(OC)and procollagen type I N-terminal propeptide(PINP)before and after treatment.Results After treatment,the total effective rate in adjuvant therapy group was higher than that in conventional treatment group(P<0.05).TCM syndrome scores,IL-1βand MMP-13 levels,PD,SBI,GI,and ALP and OC levels in both groups were lower than those before treatment,while PINP levels were higher;there were statistically significant differences in above-mentioned indicators between the two groups(P<0.05).Conclusion Guihuang Guchi Prescription as adjuvant therapy for patients with chronic periodontitis can achieve good clinical effects.It can lower the levels of IL-1βand MMP-13,and improve periodontal health as well as bone metabolism indicators.
作者
王娇
陈成
翁国建
WANG Jiao;CHEN Cheng;WENG Guo-jian(Pukou District Hospital of TCM,Nanjing 211800)
出处
《湖北中医药大学学报》
2024年第2期34-37,共4页
Journal of Hubei University of Chinese Medicine
基金
江苏省南京市卫生科技发展专项项目(项目编号:YKK20210)。
