摘要
目的探讨氯吡格雷联合他汀类调脂药治疗对冠状动脉粥样硬化性心脏病患者心绞痛症状及心功能的影响。方法选取2021年4月至2023年4月于广西壮族自治区民族医院接受住院治疗的冠状动脉粥样硬化性心脏病心绞痛患者58例作为研究对象,按随机数字表法分为对照组与观察组,各29例。对照组患者接受阿司匹林、硫酸氯吡格雷治疗,观察组患者在对照组基础上加用阿托伐他汀治疗。比较两组患者近期疗效、心绞痛症状、心功能指标,以及治疗期间药物相关不良反应发生情况。结果观察组治疗有效率高于对照组,差异有统计学意义(P<0.05);治疗后观察组每周心绞痛发作次数、单次心绞痛发作持续时间、心绞痛症状评分低于对照组,差异有统计学意义(P<0.05);治疗后观察组左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)水平低于对照组,左心室射血分数(LVEF)水平高于对照组,差异有统计学意义(P<0.05);治疗期间,观察组与对照组药物相关不良反应发生率比较差异无统计学意义(P>0.05)。结论氯吡格雷联合阿托伐他汀用于冠状动脉粥样硬化性心脏病心绞痛患者的治疗,可积极缓解心绞痛严重程度并优化心功能,提升近期治疗有效率,且具有良好的治疗安全性,是一种理想的治疗方案。
Objective To explore the effects of clopidogrel combined with statins on angina pectoris symptoms and cardiac function in patients with coronary heart disease.Methods Fifty-eight patients with angina pectoris with coronary heart disease who were hospitalized in the National Hospital of Guangxi Zhuang Autonomous Region from April 2021 to April 2023 were selected as the study objects,and were divided into control group and observation group according to random number table method,with 29 cases in each group.The control group was treated with aspirin and clopidogrel sulfate,and the observation group was treated with atorvastatin on the basis of control group.The short-term efficacy,symptoms of angina pectoris,cardiac function indexes,and the occurrence of drug-related adverse reactions during treatment were compared between the two groups.Results The effective rate of treatment in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).After treatment,the weekly angina attack frequency,single angina attack duration and angina symptom score in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the left ventricular end-systolic diameter(LVESD)and left ventricular end-diastolic diameter(LVEDD)levels in observation group were lower than those in control group,and left ventricular ejection fraction(LVEF)levels were higher than those in control group,with statistical significance(P<0.05).During treatment,there was no significant difference in the incidence of drug-related adverse reactions between the observation group and the control group(P>0.05).Conclusion Clopidogrel combined with atorvastatin for the treatment of angina pectoris patients with coronary heart disease can actively alleviate the severity of angina pectoris and optimize cardiac function,improve the short-term treatment efficiency,and have good treatment safety,which is an ideal treatment plan.
作者
潘晓芬
覃凯
苏晓琳
耿思远
PAN Xiao-Fen;QIN Kai;SU Xiao-Lin;GENG Si-Yuan(Department of Cardiology,National Hospital of Guangxi Zhuang Autonomous Region,Nanning 530000,China)
出处
《中国药物经济学》
2024年第3期60-63,67,共5页
China Journal of Pharmaceutical Economics
